A Cyclodextrin Inclusion Compound of Cyclopyrid and Preparation of Its Wettable Powder
A cyclodextrin inclusion compound and wettable powder technology, which is applied in the direction of insecticides, animal repellents, plant growth regulators, etc., can solve the problems of poor stability and poor water solubility, and achieve improved stability, High solubility and low pollution effect
Active Publication Date: 2019-02-15
EAST CHINA UNIV OF SCI & TECH +1
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- Description
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- Application Information
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Problems solved by technology
Although the applicant has also developed new formulations such as water-dispersible granules, suspensions, and emulsions in water of cyclopyridam before, the problems of poor water solubility and poor stability have not been overcome.
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0038] Example 1: Weigh 100mg of cyclopyridam and 352mg of β-cyclodextrin and add it to 10mL of water, adjust the pH of the solution to 10, stir and react at 40°C for 2h, remove the reaction solvent by distillation under reduced pressure after the reaction is completed, and vacuum dry for 24h. Cyclopyrid-β-cyclodextrin inclusion compound was obtained.
Embodiment 2
[0039]Example 2: Weigh 100mg of cyclopyridam and 352mg of β-cyclodextrin, add 10mL of 10% methanol aqueous solution, adjust the pH of the solution to 10, stir and react at 40°C for 2h, and distill off the reaction solvent under reduced pressure after the reaction is completed , Vacuum drying for 24 hours to obtain Cyclopyrid-β-cyclodextrin inclusion compound.
Embodiment 3
[0040] Example 3: Weigh 100mg of cyclopyrid, weigh 352mg of β-cyclodextrin, add 20mL of 20% ethanol aqueous solution, adjust the pH of the solution to 10, stir and react at 40°C for 2h, and distill under reduced pressure after the reaction is completed The reaction solvent was vacuum-dried for 24 hours to obtain the inclusion compound of cyclopyridin-β-cyclodextrin.
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The invention relates to a cycloxaprid-cyclodextrin inclusion compound and the preparation of wettable powder of the cycloxaprid-cyclodextrin inclusion compound. The cycloxaprid-cyclodextrin inclusion compound disclosed by the invention comprises cycloxaprid and cyclodextrin, wherein the cyclodextrin is used as a host molecule; and the cycloxaprid is used as a guest molecule, and enters the inner part of a hydrophobic cavity of the cyclodextrin in a solvent medium to form a relatively stable inclusion compound with good solubility. The invention also provides a preparation method of the cycloxaprid-cyclodextrin inclusion compound, and the formula of wettable powder of cycloxaprid-beta-cyclodextrin is optimized through carrier screening, addition agent screening and material mixing design. The cycloxaprid-cyclodextrin inclusion compound provided by the invention can effectively overcome the defects that the solubility of the cycloxaprid is low and the stability of the cycloxaprid is poor. The preparation method provided by the invention has the advantages of being simple to operate, controllable in conditions, low in cost, free from pollution to the environment, harmless to human, safe to livestock and the like, and the cycloxaprid-cyclodextrin inclusion compound has a better control effect on rice planthoppers.
Description
Technical field: [0001] The invention belongs to the field of insecticides, and in particular relates to a cyclopyrid-cyclodextrin inclusion compound, a wettable powder of the cyclopyrid-cyclodextrin inclusion compound, and a preparation method thereof. Background technique: [0002] Cyclopyrid is the first neonicotinoid insecticide that exhibits antagonism to acetylcholine receptors. It has a special mechanism of action and high insecticidal activity. It shows promising application in the control of pests that have developed severe resistance to traditional neonicotinoid insecticides. [0003] [0004] The chemical structure of cyclopyrid [0005] At present, the synthesis of cyclopyrid and the formulations of cyclopyrid insecticide wettable powder, water dispersible granule, suspension concentrate, and water emulsion have been reported in the literature. For example, the Chinese invention patent CN201110081047.1 provides an epoxy The water dispersible granule of pyrid...
Claims
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IPC IPC(8): A01N43/90A01N25/14A01P7/04
CPCA01N25/14A01N43/90
Inventor 高峰张芝平徐海燕苑志军王云谭文娟冯舒陆益奔黄雷
Owner EAST CHINA UNIV OF SCI & TECH