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A sterile medical ultrasonic coupling patch and preparation method thereof

An ultrasonic coupling and patch technology, which is applied in the field of coupling patches, can solve the problems of easy degradation and loss of viscosity, etc., and achieve the effects of improving salt resistance, non-sensitization, and excellent biocompatibility

Active Publication Date: 2017-12-05
广东速康特医食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gel formed by the carrageenan in this patent is easy to degrade when exposed to light, loses viscosity easily, and liquefies

Method used

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  • A sterile medical ultrasonic coupling patch and preparation method thereof
  • A sterile medical ultrasonic coupling patch and preparation method thereof
  • A sterile medical ultrasonic coupling patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation and performance testing of modified Tianqing glue

[0038] The raw materials for the preparation of modified Tianqing glue in groups A-D are shown in the following table:

[0039] Group

Group A

Group B

Group C

Group D

Tianqing rubber powder: vinylpyrrolidone (mass ratio)

1:3

1:4

1:5

1:6

[0040] Preparation:

[0041] (1) Take a certain amount of Tianqing rubber powder and disperse it in cold water to prepare a glue with a mass fraction of 0.4%. Under stirring, add 1mol / L hydrochloric acid solution to adjust the pH to 6, and then slowly add it to the glue. Slowly add vinyl pyrrolidone dropwise, continue to stir for 20 minutes, then ultrasonically shake the glue for 10 minutes, and pour nitrogen into it to obtain a mixture for use;

[0042] (2) Subject the mixture obtained in step (1) to γ-ray radiation treatment for 12 minutes, with a radiation dose of 3-20 kGy, and then take it out and leave it for 3 hours. Under stirring, add 2 times the volu...

Embodiment 2-6 and comparative example 1-3

[0051] Preparation of Example 2-6 and Comparative Example 1-3 Sterile Medical Ultrasound Coupling Patch

[0052] The sterile medical ultrasonic coupling patch of Examples 2-6 and Comparative Examples 1-3 of the present invention is composed of the components in percentage by weight as described in the following table:

[0053]

Embodiment 2

[0054] The preparation method of Example 2 is:

[0055] (1) Add water to the acrylate-based polyurethane, stir until it is completely dissolved, and then add modified Tianqing glue in small amounts in several times, shake and dissolve for 40 minutes to obtain a mixture;

[0056] (2) Add propylene glycol alginate and propylene glycol monooleate to the mixture obtained in step (1), raise the temperature to 50°C, keep it warm and continue stirring for 25 minutes, then add polyethylene glycol and sodium pyrrolidone carboxylate, stir and mix evenly;

[0057] (3) After the material obtained in step (2) is cooled to room temperature, the diimidazolidinyl urea is added, and the mixture is evenly stirred to prepare a finished liquid;

[0058] (4) Vacuum the finished liquid to defoam for 8 minutes, then inject it into the mold under vacuum conditions, cure, demold and perform ultraviolet sterilization, and then package to obtain a sterile medical ultrasonic coupling patch. The described ultravio...

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Abstract

The invention relates to a sterile medical ultrasonic coupling patch and a preparation method thereof. The sterile medical ultrasonic coupling patch is prepared from the following components in percentage by weight: 10%-15% of waterborne polyurethane, 10%-25% of cationic sesbania gum, 4%-8% of propylene glycol alginate, 2%-6% of propylene glycol monooleate, 4%-12% of polyethylene glycol, 2%-8% of sodium pyrrolidone carboxylate, 0.01%-0.05% of a preservative and the balance of deionized water. The sterile medical ultrasonic coupling patch has light stability and thermal stability, the acoustic performance closest to soft tissues of the human body, high ultrasonic diagnosis accuracy and excellent biocompatibility and has no toxicity, allergenicity and stimulation to skin cells and is high in safety.

Description

Technical field [0001] The invention relates to a coupling patch, in particular to a sterile medical ultrasonic coupling patch and a preparation method thereof. Background technique [0002] With the continuous improvement and improvement of the clarity and resolution of the clinical ultrasound diagnostic technology images, the application of ultrasound examination has become more widespread. Medical ultrasonic couplant plays an extremely important role in improving the clarity and resolution of ultrasonic diagnostic technology. The medical ultrasonic couplant can expel the air between the ultrasound probe and the human tissue, thereby establishing an efficient and fidelity ultrasound transmission channel. The ideal couplant should have good acoustic performance, clear images, and high resolution; it is non-toxic and non-toxic to humans. It is irritating and has good biocompatibility with skin and mucous membranes; it does not damage the ultrasound probe and does not pollute clo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22C08B37/00
CPCA61K49/222C08B37/0003
Inventor 胡波宋雨润王英男王志吉万柏钢
Owner 广东速康特医食品科技有限公司