A Permanent Magnetic Sealing Experimental Apparatus for Protein Crystallization
A protein crystallization and experimental device technology, applied in the field of permanent magnetic closed experimental devices, can solve the problems of small permanent magnetic device, inconvenient use, high manpower and material resources, etc., to achieve small experimental space occupation, easy to move, and reduce external consumption scattered effect
Active Publication Date: 2019-05-10
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology
The electromagnetic field can be divided into a conventional conductor magnetic field and a superconducting magnetic field. The electromagnetic field can generate a high magnetic field under the action of an electric current, ranging from a few tesla to tens of tesla. Although the electromagnetic field has a high Magnetic field strength, but in the process of use, it needs a special site, high manpower and material resources to maintain, the investment is large, and it is inconvenient to use
On the other hand, as far as the permanent magnetic field is concerned, its magnetic field strength can reach up to a few tesla at present. Although its strength is much smaller than that of the electromagnetic field, the permanent magnetic field device is small in size, and once the device is assembled, it does not need to Carry out energy input and the same complicated maintenance as electromagnetic fields
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[0022] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, and the present invention includes but not limited to the following embodiments.
[0023] The invention provides a permanent magnetic sealing experimental device for biological protein crystallization, which includes an internal test system of the device and an external sealing system of the device.
[0024] The internal experimental system of the device includes: a strong permanent magnet, a supporting U-shaped thick antimagnetic hard aluminum plate (U-shaped aluminum plate), a crystallization plate placement area and an antimagnetic air space.
[0025] The external closure system of the device includes: paramagnetic steel plates, antimagnetic aluminum plates, paramagnetic screw rods, antimagnetic cylindrical pins, device entrances and entrance door covers.
[0026] As a preferred solution of the above technology, the internal experimental system of the ...
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Abstract
The invention provides a permanent magnet closed experimental device for protein crystallization. Two permanent magnets are placed in parallel, and the polarities of corresponding positions of the two permanent magnets are opposite; a U-shaped aluminum plate is located between the two permanent magnets, and the aluminum plate and the permanent magnets define a crystallization plate accommodating zone with five sides closed and one side open; multiple paramagnetic steel plates and diamagnetic aluminum plates define a closed structure to wrap the permanent magnets and the U-shaped aluminum plate, and in the closed structure, the diamagnetic aluminum plates are arranged on two sides directly facing the opening of the U-shaped aluminum plate. The permanent magnet closed experimental device is high magnetic field intensity, compact in size, low in manufacturing cost and capable of obviously improving the protein crystallization quality.
Description
technical field [0001] The invention relates to the field of biological experimental equipment, in particular to a permanent magnetic sealing experimental device for biological protein crystallization. Background technique [0002] Protein is the main bearer of life activities, with extremely variable structures and functions, so its importance to life activities is self-evident. Through the analysis of protein structure and function analysis, we can have a deeper understanding and research on life activities. [0003] At present, the analysis of protein structure is mainly done by means of XRD (X-ray diffraction), and more than 90% of protein structures in the PDB (Protein Data Bank) database are analyzed by XRD. At present, XRD has an absolute dominant position in the process of protein structure analysis, but using XRD to analyze protein structure requires the use of protein crystals, so protein crystallization has become a key step in XRD protein structure analysis. In ...
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IPC IPC(8): G01N1/28G01N23/207H01F7/02
CPCG01N1/28G01N23/20G01N2223/056G01N2223/1016G01N2223/612H01F7/0263
Inventor 尹大川郑希望曾祥斌张斌商澎
Owner NORTHWESTERN POLYTECHNICAL UNIV