A kind of preparation method of drug-loaded polypyrrole/sodium alginate gel

A kind of technology of sodium alginate and polypyrrole, applied in the field of polymer

Active Publication Date: 2019-05-28
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drug sustained-release hydrogel materials are mainly biocompatible high polymers such as polyvinyl alcohol, sodium alginate, chitosan, silk fibroin, and polyamide. Glue is less reported

Method used

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  • A kind of preparation method of drug-loaded polypyrrole/sodium alginate gel
  • A kind of preparation method of drug-loaded polypyrrole/sodium alginate gel
  • A kind of preparation method of drug-loaded polypyrrole/sodium alginate gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Dissolve 25mg of sodium alginate in 25mL of ionized water to prepare sodium alginate solution;

[0029] (2) Dissolve 0.4g pyrrole monomer in 50mL 1mol / L HCl solution to prepare pyrrole monomer solution;

[0030] (3) Dissolve 4mg of acetylsalicylic acid in 40mL of 1mol / L HCl solution to prepare a drug solution;

[0031] (4) Under magnetic stirring, drop the drug solution prepared in step (3) into the pyrrole monomer solution obtained in step (2), and stir for 15 minutes after the dropping;

[0032] (5) Under magnetic stirring, the drug-dissolved pyrrole monomer solution obtained in step (4) was added dropwise to the sodium alginate solution prepared in step (1), and after the addition was completed, ultrasonically dispersed for 15 minutes;

[0033] (6) Add 0.8g 30%H 2 o 2 Dissolve in 40mL deionized water, mix well; under ice bath condition, put H 2 o 2 The solution was slowly added dropwise to the mixed solution obtained in step (5). During the dropwise addition...

Embodiment 2

[0048] (1) Dissolve 75mg of sodium alginate in 25mL of ionized water to prepare sodium alginate solution;

[0049] (2) Dissolve 0.4g pyrrole monomer in 25mL 1mol / L HCl solution to prepare pyrrole monomer solution;

[0050] (3) Dissolve 20 mg of methotrexate in 40 mL of 1mol / L HCl solution to prepare a drug solution;

[0051] (4) Under magnetic stirring, drop the drug solution prepared in step (3) into the pyrrole monomer solution obtained in step (2), and stir for 30 minutes after the dropping;

[0052] (5) Under magnetic stirring, the drug-dissolved pyrrole monomer solution obtained in step (4) was added dropwise to the sodium alginate solution prepared in step (1), and after the addition was completed, ultrasonically dispersed for 25 minutes;

[0053] (6) 1.2g 30%H 2 o 2 Dissolve in 30mL deionized water, mix well; under ice bath condition, put H 2 o 2 The solution was slowly added dropwise to the mixed solution obtained in step (5). During the dropwise addition, magneti...

Embodiment 3

[0056] (1) Dissolve 50 mg of sodium alginate in 25 mL of ionized water to prepare a sodium alginate solution;

[0057] (2) Dissolve 0.4g pyrrole monomer in 40mL 1mol / L HCl solution to prepare pyrrole monomer solution;

[0058] (3) Dissolve 16 mg of dexamethasone in 40 mL of 1mol / L HCl solution to prepare a drug solution;

[0059] (4) Under magnetic stirring, drop the drug solution prepared in step (3) into the pyrrole monomer solution obtained in step (2), and stir for 20 minutes after the dropping;

[0060] (5) Under magnetic stirring, the drug-dissolved pyrrole monomer solution obtained in step (4) was added dropwise to the sodium alginate solution prepared in step (1), and after the addition was completed, ultrasonically dispersed for 20 minutes;

[0061] (6) Add 1.0g 30%H 2 o 2 Dissolve in 40mL deionized water, mix well; under ice bath condition, put H 2 o 2 The solution was slowly added dropwise to the mixed solution obtained in step (5). During the dropwise addition...

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Abstract

The invention provides a preparation method for medicine-carrying polypyrrole / sodium alginate gel. The method comprises the following steps: by taking a natural high polymer sodium alginate as a structural guiding agent, forming a monomer compound by virtue of electrostatic attraction between carboxyl in a sodium alginate molecular structure and an amino in a pyrrole monomer; preparing polypyrrole / sodium alginate microspheres through in-situ oxidative polymerization; and then forming the medicine-carrying polypyrrole / sodium alginate gel by virtue of rapid ion exchange reaction between the sodium alginate and calcium ions. The medicine-carrying polypyrrole / sodium alginate gel obtained by the method has excellent double response performances of pH and electric field.

Description

technical field [0001] The invention belongs to the technical field of macromolecules and the technical field of drug sustained release, and in particular relates to a preparation method of drug-loaded polypyrrole / sodium alginate gel. Background technique [0002] Drug sustained-release system is conducive to improving drug efficacy, reducing side effects, and can reduce the pain of patients with multiple medications, which is of great significance to improving the level of clinical medication. Hydrogels are usually water-swellable polymers formed by hydrophilic monomers and crosslinking agents. The rich water in the hydrogel allows the dissolved substances and low-molecular-weight substances to permeate and diffuse from it. At the same time, since a large amount of water is flooded in the polymer network, the cross-linked macromolecular chains are stretched to a large extent, so that the whole material has a fluid property, which is very similar to human tissue containing a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/06
CPCA61K9/06A61K47/36
Inventor 彭勇刚孔泳汪媛纪俊玲陶永新
Owner CHANGZHOU UNIV
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