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Electroactive degradable supermolecule microgel/medicine carrying supermolecule microgel and preparation method and application thereof

A supramolecular and microgel technology, which is applied in the directions of organic active ingredients, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of low yield of microgels and lack of multi-responsive drug control. release, poor stability and other problems, to achieve the effect of simple preparation method, good potential practical value and low cost

Active Publication Date: 2019-12-06
NANJING FORESTRY UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to overcome the deficiencies in the prior art and provide a degradable supramolecular microgel with electroactivity and its preparation method. Another purpose of the present invention is to provide a degradable supramolecular microgel with electroactivity. Drug-loaded supramolecular microgel and preparation method thereof, to overcome the problems of low yield and poor stability of microgel prepared by existing methods and lack of multi-responsive drug controlled release

Method used

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  • Electroactive degradable supermolecule microgel/medicine carrying supermolecule microgel and preparation method and application thereof
  • Electroactive degradable supermolecule microgel/medicine carrying supermolecule microgel and preparation method and application thereof
  • Electroactive degradable supermolecule microgel/medicine carrying supermolecule microgel and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0050] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0051] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0052] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone The ratio is 1:0.33, stir evenly, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform water phase for later use;

[0053] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0054] d: Introduce argon gas into the water pha...

Embodiment 2

[0058] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0059] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0060] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone The ratio is 1:0.5, stir evenly, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform water phase for later use;

[0061] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0062] d: Introduce argon gas into the water phas...

Embodiment 3

[0066] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0067] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0068] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone 1:1, stir evenly, ultrasonically disperse in a water bath for 2 minutes, obtain a uniform water phase, and set aside;

[0069] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0070] d: Introduce argon gas into the water phase prepared in step b...

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Abstract

The invention provides electroactive degradable supermolecule microgel / medicine carrying supermolecule microgel and a preparation method and application thereof. The supermolecule microgel comprises chitosan, hydroquinone and auxiliary materials. The preparation method comprises the steps of preparing an aqueous phase containing chitosan and hydroquinone, and a cyclohexane organic phase containingspan 80; and enabling the electroactive degradable supermolecule microgel / medicine carrying supermolecule microgel to be synthetized by a water-in-oil inverse microemulsion polymerizing method, wherein the chitosan and the hydroquinone are cross-linked through the action of hydrogen bonds of aminos and hydroxyls, and the mass ratio of the chitosan to the hydroquinone is 1 to (0.33-3). The supermolecule microgel can efficiently carry doxorubicin hydrochloride, and the medicine carrying supermolecule microgel can be synthetized. The medicine carrying supermolecule microgel can be dually degraded by urea and lysozyme, the controlled-release application of medicines under particular environment is realized, and a new method is provided for development of a multi-response medicine transportingplatform.

Description

technical field [0001] The invention relates to the field of preparation of multi-responsive drug-loaded nano-platforms, in particular to a degradable drug-loaded supramolecular microgel with electroactivity and its preparation and application. Background technique [0002] In recent years, degradable and highly biocompatible natural polymer materials have attracted extensive attention in the fields of tissue engineering and drug controlled release carriers. By degrading the carrier for transporting drugs, the purpose of controlled release of drugs in the body can be achieved. At present, natural biopolymers that are widely used include cellulose, chitosan, dextran, alginate, pullulan, chondroitin sulfate, and hyaluronic acid. In order to achieve wider applications, these natural biopolymers Molecular materials are used to prepare microgel drug carriers with high water content and high hydrophilicity. The microgel drug carrier has the advantages of high biocompatibility, b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/10A61K31/704A61P35/00C08J3/075C08L5/08
CPCA61K9/06A61K47/36A61K47/10A61K31/704A61P35/00C08J3/075C08J2305/08
Inventor 李和霖曹肖兵李延军李鑫
Owner NANJING FORESTRY UNIV
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