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Molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound preparation method

A technology of mesoporous organosilicon and molybdenum disulfide, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of systemic side effects, short remission period, poor water solubility, etc., and achieve good water dispersibility and biological properties. Effects of compatibility, high drug loading, and mild reaction conditions

Active Publication Date: 2018-04-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, chemotherapy plays a dominant role in the comprehensive treatment of tumors, but chemotherapy drugs can cause systemic toxic and side effects during tumor treatment, which severely limits its clinical use.
At the same time, traditional chemotherapy drugs still have certain limitations, such as poor water solubility and cross-drug resistance.
Disadvantages such as short remission period and obvious side effects
Therefore, the efficacy of such treatment methods needs to be improved

Method used

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  • Molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound preparation method
  • Molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound preparation method
  • Molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Disperse 1.0g CTAB in a mixed solvent of 20mL deionized water and 45mL ethanol, heat to 35°C, and stir to dissolve. Then 1 mL of ammonia water was added and stirred for 1 hour. Then add 0.45mL TEOS and 0.15mL BTES, continue to react for 2 hours, wash with water, wash with alcohol, and centrifuge at 10000rpm to obtain precipitates that are sulfur-doped periodic mesoporous organic silicon nanoparticles. Reflux the precipitate in a mixed solution of 120 mL of hydrochloric acid / methanol (2:85 by volume) for 6 hours, then centrifuge to obtain the precipitate, repeat the above reflux operation three times, centrifuge and freeze-dry to obtain sulfur-doped periodic mesoporous Silicone nanoparticles (PMOs).

[0042] (2) Disperse 10 mg of PMOs in 10 mL of PBS solution with a pH value of 7.4. While stirring, add 10 mL of DOX-containing PBS solution (0.5 mg / mL) dropwise, and stir at room temperature for 4 h. Finally, put the PMOs solution containing doxorubicin (DOX) into a d...

Embodiment 2

[0047] (1) Disperse 1.0g CTAB in a mixed solvent of 15mL deionized water and 30mL ethanol, heat to 45°C, and stir to dissolve. Then 0.7 mL of ammonia water was added and stirred for 1 hour. Then add 0.7mL TEOS and 0.14mL BTES, continue to react for 3 hours, wash with water, wash with alcohol, and centrifuge at 10000rpm to obtain precipitates that are sulfur-doped periodic mesoporous organic silicon nanoparticles. Reflux the precipitate in a mixed solution of 120 mL of hydrochloric acid / methanol (2:85 by volume) for 6 hours, then centrifuge to obtain the precipitate, repeat the above reflux operation three times, centrifuge and freeze-dry to obtain sulfur-doped periodic mesoporous Silicone nanoparticles (PMOs).

[0048] (2) Disperse 15 mg of PMOs in 15 mL of PBS solution with a pH value of 7.4. While stirring, add 5 mL of DOX-containing PBS solution (1 mg / mL) dropwise, and stir at room temperature for 4 h. Finally, put the PMOs solution containing doxorubicin (DOX) into a dia...

Embodiment 3

[0053] (1) Disperse 2.0g CTAB in a mixed solvent of 30mL deionized water and 70mL ethanol, heat to 55°C, and stir to dissolve. Then 2 mL of ammonia water was added and stirred for 1 hour. Then add 1.4mL TEOS and 0.32mL BTES, continue to react for 1 hour, wash with water, wash with alcohol, and centrifuge at 10000rpm to obtain precipitates that are sulfur-doped periodic mesoporous organic silicon nanoparticles. Reflux the precipitate in a mixed solution of 120 mL hydrochloric acid / methanol (2:85) for 6 hours, then centrifuge to obtain the precipitate, repeat the above reflux operation three times, centrifuge and freeze-dry to obtain sulfur-doped periodic mesoporous organosilicon nanoparticles Particles (PMOs).

[0054] (2) Disperse 20 mg of PMOs in 15 mL of PBS solution with a pH of 7.4. While stirring, add 7 mL of DOX-containing PBS solution (1 mg / mL) dropwise, and stir at room temperature for 4 h. Finally, put the PMOs solution containing doxorubicin (DOX) into a dialysis b...

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Abstract

The invention relates to a molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound preparation method which comprises the steps: preparing sulfur-doped periodic mesoporous organic-silicon nanoparticles PMOs, preparing drug loading periodic mesoporous organic-silicon nano drug loading system PMOs-DOX, preparing molybdenum disulfide quantum dot MDs dispersion liquid and preparing molybdenum disulfide quantum dot loaded periodic mesoporous organic-silicon nano drug loading compound PMOs-DOX@MDs. The method disclosed by the invention has the advantages of simpleness, easiness in operation, moderate reaction conditions and a industrialization application prospect; the prepared PMOs-DOX@MDs has better water dispersibility and biological compatibility and high drug loading amount, can achieve long-acting slow release, has a high release rate under a lower pH value environment and is suitable for tumor tissue microenvironments; furthermore, the PMOs-DOX@MDs can generate hyperthermia under lower-power laser irradiation to perform photothermal therapy.

Description

technical field [0001] The invention belongs to the field of preparation of nanocarriers, in particular to a preparation method of a periodic mesoporous organic silicon nanometer drug-loaded compound supported by molybdenum disulfide quantum dots. Background technique [0002] Tumors seriously threaten human health and even life. Traditional treatment methods, mainly including chemotherapy and radiation therapy, have limited final therapeutic effect due to severe side effects. At present, chemotherapy plays a dominant role in the comprehensive treatment of tumors, but chemotherapy drugs can cause systemic side effects during tumor treatment, which severely limits their clinical use. At the same time, traditional chemotherapy drugs still have certain limitations, such as poor water solubility and cross-drug resistance. Disadvantages such as short remission period and obvious side effects. Therefore, the efficacy of this type of treatment needs to be improved. [0003] Pho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/24A61P35/00
CPCA61K31/704A61K41/0052A61K47/24A61K2300/00
Inventor 朱利民吴建荣牛世伟李赫宇
Owner DONGHUA UNIV
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