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Double network polymer hydrogel and preparation method thereof

A polymer and hydrogel technology, applied in the field of biomedical materials, can solve the problems of unreported research, fragile, unsatisfactory response rate, etc., and achieve the effect of wide application prospects.

Active Publication Date: 2012-09-05
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, poly 2-acrylamide-2-methylpropanesulfonic acid (AMPS) electroresponsive gel has low strength and is easily broken during operation; N-isoacrylamide (PNIPAAM), acrylamide (AAm) The gel has high strength and stable performance, has certain swelling performance and gel strength, and is responsive to temperature or electric field, but the response rate cannot meet the practical requirements
At present, there is no report on the double-network polymer hydrogel formed by the in-situ polymerization of polyethylene glycol maleic anhydride ester and N-isopropylacrylamide, acrylamide and other hydrophilic monomers.

Method used

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  • Double network polymer hydrogel and preparation method thereof
  • Double network polymer hydrogel and preparation method thereof
  • Double network polymer hydrogel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Step 1. After drying and removing water, 2g polyethylene glycol (PEG) with a molecular weight of 200, 1.86g maleic anhydride, and 5mL toluene were added to the reaction vessel, sealed, evacuated, replaced with nitrogen, and stirred at 65℃ After 10 hours, the reaction was stopped, and the toluene in the reaction vessel was evaporated to dryness by rotary evaporation to obtain polyethylene glycol maleic anhydride diester.

[0047] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 10-20 mL of dichloromethane, then precipitate in 100-200 mL n-hexane, and obtain pure polyethylene glycol maleic anhydride diester after suction filtration;

[0048] Step 3. Mix 0.24g product A with 0.083g N-isopropylacrylamide monomer after drying and purification, 0.067g potassium persulfate, 0.0616g N,N-methylenebisacrylamide (BIS), add 3 ~4mL of double distilled water, mixed and stirred uniformly, heated in the reaction vessel to 75°C and reacted for 2h to obtain DN polymer gel.

[0...

Embodiment 2

[0054] Step 1. After drying and removing water, 4g polyethylene glycol (PEG) with molecular weight of 400, 2.41g maleic anhydride and 8mL toluene were added to the reaction vessel, sealed, evacuated, replaced by nitrogen, and stirred at 65℃ After 10 hours, the reaction was stopped, and the solvent in the reaction vessel was evaporated to dryness by rotary evaporation to obtain polyethylene glycol maleic anhydride diester.

[0055] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 12 mL of dichloromethane, and then precipitate in 120 mL of anhydrous ether, and obtain product A after suction filtration;

[0056] Step 3. Mix 0.45g product A with 0.148g acrylamide monomer after drying and purification, add 0.026g 2,2-dimethoxy-2-phenylacetophenone (DMPA), add 3.5mL double distilled water In the process, mix and stir uniformly, move to a mold, and irradiate under 500W ultraviolet light for 20 minutes to obtain a dual-network polymer hydrogel.

[0057] Step 4. Then cut the ...

Embodiment 3

[0060] Step 1. After drying and removing water, 8g polyethylene glycol (PEG) with a molecular weight of 800, 2.88g maleic anhydride, and 14mL toluene were added to the reaction vessel, sealed, evacuated, replaced by nitrogen, and stirred at 70℃ After 15 hours, the reaction was stopped, the organic solvent in the reaction vessel was evaporated to dryness, and polyethylene glycol maleic anhydride diester was obtained.

[0061] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 16 mL of dichloromethane, then precipitate in 160 mL of n-hexane, and obtain product A after suction filtration.

[0062] Step 3. Mix 0.79g product A with 0.159g N-isopropylacrylamide monomer after drying and purification, 0.089g ammonium persulfate, 0.0674g ethylene glycol dimethacrylate (EGDMA), and add 3.8mL dimethacrylate Distilled water twice, mixed and stirred uniformly, heated in a reaction vessel to 75°C for 2 hours to obtain DN polymer gel.

[0063] Step 4. Then cut the dual network polyme...

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Abstract

A double network polymer hydrogel and a preparation method thereof provided in the invention, relate to a biomedical material. The polymer hydrogel comprises the following ingredients: 60-90wt% of polyethylene glycol maleic anhydride diester and N-isopropyl acrylamide or acrylamide copolymer, and 10-40wt% of N-isopropyl acrylamide or acrylamide homopolymer. The preparation method comprises the following two steps: first, utilizing an esterification reaction between polyethylene glycol PEG and maleic anhydride to obtain polyethylene glycol maleic anhydride diester with carboxyl as end group, then carrying out in situ polymerization, chemical crosslinking or UV photo-initiation crosslinking between polyethylene glycol maleic anhydride diester and a functional monomer such as N-isopropyl acrylamide or acrylamide and the like to form a soft network micro-area by the copolymer and form a hard network framework by the homopolymer of the functional monomer, so as to obtain the double networkpolymer hydrogel consisting of the soft network micro-area and the hard network framework. According to the invention, the hydrophilcity and biocompatibility of the hydrogel are improved, and the hydrophilcity has high mechanical strength, and sensitivities of rapid PH, temperature and electric field. The preparation method is simple and easy for industrialization.

Description

Technical field [0001] The invention relates to a biomedical material, in particular to a dual-network polymer hydrogel with pH, ​​temperature and electric field sensitivity and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked polymer network that can swell and retain a large amount of water in water or biological fluids, but cannot be dissolved. Since the 1970s, it has been studied by materials science and biomedical workers due to its unique water absorption and good biocompatibility. It has been widely used in sanitary products, drug delivery systems, contact lenses, wastewater treatment, and anti-corrosion. Static electricity, sealing materials, cold storage agents, solvent dehydration, packaging materials and many other fields. Generally, we call a type of polymer gel that can perceive small changes or stimuli in the external environment (such as temperature, pH, light, electricity, pressure, etc.) and produce corresponding changes in p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L51/08C08L33/24C08L33/26C08F290/06C08F220/56C08F220/54C08F120/56C08F120/54C08G65/48
Inventor 戴李宗邓胡军陈光剑郭一宾许一婷罗伟昂
Owner XIAMEN UNIV
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