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Double network polymer hydrogel and preparation method thereof

A polymer and hydrogel technology, applied in the field of biomedical materials, can solve the problems of unreported research, unsatisfactory response rate, low strength of electroresponsive gel, etc., and achieve the effect of wide application prospects

Active Publication Date: 2011-10-26
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, poly 2-acrylamide-2-methylpropanesulfonic acid (AMPS) electroresponsive gel has low strength and is easily broken during operation; N-isoacrylamide (PNIPAAM), acrylamide (AAm) The gel has high strength and stable performance, has certain swelling performance and gel strength, and is responsive to temperature or electric field, but the response rate cannot meet the practical requirements
At present, there is no report on the double-network polymer hydrogel formed by the in-situ polymerization of polyethylene glycol maleic anhydride ester and N-isopropylacrylamide, acrylamide and other hydrophilic monomers.

Method used

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  • Double network polymer hydrogel and preparation method thereof
  • Double network polymer hydrogel and preparation method thereof
  • Double network polymer hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Step 1. Add 2g of polyethylene glycol (PEG) with a molecular weight of 200 after drying and removing water, 1.86g of maleic anhydride, and 5mL of toluene into the reaction vessel, seal it, vacuumize it, replace it with nitrogen, and stir at 65°C After 10 hours, the reaction was stopped, and the toluene in the reaction vessel was evaporated to dryness to obtain polyethylene glycol maleic anhydride diester.

[0047] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 10-20 mL of dichloromethane, then precipitate in 100-200 mL of n-hexane, and obtain pure polyethylene glycol maleic anhydride diester after suction filtration;

[0048] Step 3. Mix 0.24g of product A with 0.083g of dried and purified N-isopropylacrylamide monomer, 0.067g of potassium persulfate, 0.0616g of N,N-methylenebisacrylamide (BIS), and add 3 ~4mL double distilled water, mix and stir evenly, heat up to 75°C in the reaction vessel and react for 2h to obtain DN polymer gel.

[0049] Step 4,...

Embodiment 2

[0054] Step 1. Add 4g of polyethylene glycol (PEG) with a molecular weight of 400 after drying and removing water, 2.41g of maleic anhydride, and 8mL of toluene into the reaction vessel, seal it, vacuumize it, replace it with nitrogen, and stir at 65°C After 10 hours, the reaction was stopped, and the solvent in the reaction vessel was evaporated to dryness to obtain polyethylene glycol maleic anhydride diester.

[0055] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 12 mL of dichloromethane, then precipitate in 120 mL of anhydrous ether, and obtain product A after suction filtration;

[0056] Step 3. Mix 0.45g of product A with 0.148g of dry and purified acrylamide monomer, add 0.026g of 2,2-dimethoxy-2-phenylacetophenone (DMPA), and add 3.5mL of double distilled water , mixed and stirred evenly, moved to a mold, and irradiated under 500W ultraviolet light for 20 minutes to obtain a double-network polymer hydrogel.

[0057] Step 4, then cut the double netwo...

Embodiment 3

[0060] Step 1. Add 8g of polyethylene glycol (PEG) with a molecular weight of 800 after drying and removing water, 2.88g of maleic anhydride, and 14mL of toluene into the reaction vessel, seal it, vacuumize it, replace it with nitrogen, and stir at 70°C After 15 hours, the reaction was stopped, and the organic solvent in the reaction vessel was evaporated to dryness to obtain polyethylene glycol maleic anhydride diester.

[0061] Step 2. Dissolve polyethylene glycol maleic anhydride diester in 16 mL of dichloromethane, then precipitate in 160 mL of n-hexane, and obtain product A after suction filtration.

[0062] Step 3. Mix 0.79g of product A with 0.159g of dried and purified N-isopropylacrylamide monomer, 0.089g of ammonium persulfate, 0.0674g of ethylene glycol dimethacrylate (EGDMA), and add 3.8mL of dimethacrylate Subdistilled water, mixed and stirred evenly, heated up to 75°C in the reaction vessel and reacted for 2 hours to obtain DN polymer gel.

[0063] Step 4, then cu...

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Abstract

A double network polymer hydrogel and a preparation method thereof provided in the invention, relate to a biomedical material. The polymer hydrogel comprises the following ingredients: 60-90wt% of polyethylene glycol maleic anhydride diester and N-isopropyl acrylamide or acrylamide copolymer, and 10-40wt% of N-isopropyl acrylamide or acrylamide homopolymer. The preparation method comprises the following two steps: first, utilizing an esterification reaction between polyethylene glycol PEG and maleic anhydride to obtain polyethylene glycol maleic anhydride diester with carboxyl as end group, then carrying out in situ polymerization, chemical crosslinking or UV photo-initiation crosslinking between polyethylene glycol maleic anhydride diester and a functional monomer such as N-isopropyl acrylamide or acrylamide and the like to form a soft network micro-area by the copolymer and form a hard network framework by the homopolymer of the functional monomer, so as to obtain the double network polymer hydrogel consisting of the soft network micro-area and the hard network framework. According to the invention, the hydrophilcity and biocompatibility of the hydrogel are improved, and the hydrophilcity has high mechanical strength, and sensitivities of rapid PH, temperature and electric field. The preparation method is simple and easy for industrialization.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a double-network polymer hydrogel sensitive to pH, temperature and electric field and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked polymer network that can swell and retain a large amount of water in water or biological fluids without dissolving. Since the 1970s, it has been studied by material science and biomedical workers because of its unique water absorption and good biocompatibility, and has been widely used in physiological hygiene products, drug delivery systems, contact lenses, wastewater treatment, and anti-aging Static electricity, sealing materials, cooling agents, solvent dehydration, packaging materials and many other fields. Usually, we call a type of polymer gel that can perceive small changes or stimuli in the external environment (such as temperature, pH, light, electricity, pressure, etc.), and can produce corresponding changes...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L51/08C08L33/24C08L33/26C08F290/06C08F220/56C08F220/54C08F120/56C08F120/54C08G65/48
Inventor 戴李宗邓胡军陈光剑郭一宾许一婷罗伟昂
Owner XIAMEN UNIV
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