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Content detection method of musk bone strengthening medicine composition

A detection method and composition technology, applied in the field of medicine, can solve the problems that the detection method of Musk Zhuanggu Paste has not been found, diphenhydramine hydrochloride and methyl salicylate have not been found, and the quality standard of Musk Zhuanggu Paste needs to be improved.

Active Publication Date: 2017-05-17
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, no determination of the content of diphenhydramine hydrochloride and methyl salicylate using the same chromatographic conditions has been found, and no other detection methods for Musk Zhuanggu Paste have been found. The quality standard of Musk Zhuanggu Paste needs to be improved

Method used

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  • Content detection method of musk bone strengthening medicine composition
  • Content detection method of musk bone strengthening medicine composition
  • Content detection method of musk bone strengthening medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] A method for detecting the content of traditional Chinese medicine Musk Zhuanggu Ointment, the steps are as follows:

[0098] Measured according to Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography:

[0099] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; methanol-1% (g / V) ammonium sulfate solution is used as mobile phase with a volume fraction ratio of 50:50, and the detection wavelength is 210nm; theoretical The number of plates should not be less than 3000 based on the diphenhydramine hydrochloride peak;

[0100] The preparation of reference substance solution: get diphenhydramine hydrochloride reference substance and methyl salicylate reference substance appropriate amount, accurately weighed, add 80% (V / V) methyl alcohol to make every 1mL containing diphenhydramine hydrochloride 0.4mg, For the mixed solution of methyl salicylate 1.6mg, take 5mL and put it i...

Embodiment 2

[0105] A content detection method of musk bone-strengthening medicinal composition, the steps are as follows:

[0106] According to the Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography determination.

[0107]Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler; methanol-1% (g / V) ammonium sulfate solution with a volume ratio of 45:55 is used as mobile phase, and the detection wavelength is 210nm. The number of theoretical plates should not be less than 3000 based on the diphenhydramine hydrochloride peak.

[0108] Preparation of reference substance solution: Take appropriate amount of diphenhydramine hydrochloride reference substance and methyl salicylate reference substance, accurately weighed, add 90% methanol to make every 1mL containing diphenhydramine hydrochloride 0.2mg, methyl salicylate Take 0.8mg of the mixed solution, take 5mL and put it in a 10mL volumetric flask,...

Embodiment 3

[0113] A content detection method of musk bone-strengthening medicinal composition, the steps are as follows:

[0114] According to the Chinese Pharmacopoeia 2015 edition four general rules 0512 high performance liquid chromatography determination.

[0115] Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler; methanol-1% (g / V) ammonium sulfate solution with a volume ratio of 55:45 is used as mobile phase, and the detection wavelength is 210nm. The number of theoretical plates should not be less than 3000 based on the diphenhydramine hydrochloride peak.

[0116] The preparation of reference substance solution: get diphenhydramine hydrochloride reference substance and methyl salicylate reference substance appropriate amount, accurately weighed, add 80% (V / V) methyl alcohol to make every 1mL containing diphenhydramine hydrochloride 0.2mg, For the mixed solution of methyl salicylate 0.8mg, take 5mL and put it in a 10mL volum...

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Abstract

The invention relates to a content detection method of a musk bone strengthening medicine composition. The same chromatographic condition is used for simultaneously detecting the contents of diphenhydramine hydrochloride and methyl salicylate in the musk bone strengthening medicine composition; the operation is simple, convenient and fast; the detection cost is low; the detection result is accurate; the reproducibility is high; the recipe composition of musk bone strengthening paste can be comprehensively reflected. The content detection method can be used for the content determination of the musk bone strengthening medicine composition.

Description

technical field [0001] The invention relates to a content detection method of a musk bone-strengthening pharmaceutical composition, which belongs to the technical field of medicine. Background technique [0002] Musk Zhuang Gu Ointment is included in the 1996 edition of the Ministry of Health of the People's Republic of China Drug Standards of Traditional Chinese Medicine Prescriptions Volume 11. Musk Zhuanggu Ointment has analgesic and anti-inflammatory effects. For rheumatic pain, arthralgia, low back pain, neuralgia, muscle aches, sprains, contusions. [0003] The formula composition of musk strong bone cream is as follows: star anise, kaempferen, raw Chuanwu, raw grass aconitum, ephedra, herb, angelica, angelica, dried ginger, artificial musk, menthol, methyl salicylate, sodium chondroitin sulfate, Borneol, diphenhydramine hydrochloride, camphor, etc. The auxiliary materials are rubber, zinc oxide, lithopone, rosin, vaseline, and lanolin. Shexiang Zhuanggu Ointment h...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 吴世德胡安平贾美春马双张秋菊李晶王春谭倩鲁英姿王焕
Owner SHANDONG MINGREN FURUIDA PHARMA
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