Amphipathic segmented copolymer micelle compound drug loading and delivery system and preparation method of brain-targeted water-soluble micelle

A water-soluble glue, brain-targeting technology, which can be used in medical preparations without active ingredients, medical preparations containing active ingredients, drug combinations, etc. , reduce the problems of patient compliance, and achieve the effect of overcoming the easy resistance of single drugs, reducing the economic burden of patients, and reducing the single dose of administration.
CN106692053AInactive Publication Date: 2017-05-24SHANGHAI CHANGHAI HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI CHANGHAI HOSPITAL
Publication Date
2017-05-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a brain-targeted water-soluble micelle. The brain-targeted water-soluble micelle is characterized in that a compound nano micelle loaded with paclitaxel and lapatinib is connected with a short peptide molecule Angiopep-2 of a cerebral endothelial cell. In the brain-targeted water-soluble micelle, the drug loading micelle having a brain-targeted function is prepared on the basis by preparing the compound water-soluble drug loading nano micelle. The molecule is connected with the targeted molecule Angiopep-2 by utilizing amidogen and carboxyl bonds, and the nano drug loading micelle having the brain-targeted function is prepared.
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Description

technical field

[0001] The invention relates to the field of brain-targeting preparations, in particular to an amphiphilic block copolymer micelle compound drug delivery system and a method for preparing brain-targeting water-soluble micelles. Background technique

[0002] Taxanes (paclitaxel, docetaxel) are currently one of the main drugs for the treatment of metastatic breast cancer. Although taxanes are widely used, they have many unavoidable side effects, including: hair loss, fatigue, muscle pain , bone marrow suppression, neurotoxicity, allergic reactions, etc.

[0003] At the same time, taxanes are highly insoluble in water, and their solubility in water is 0.5 μg / ml, so polyoxyethylene castor oil and absolute ethanol (1:1, V / V) should be used as cosolvents during administration. However, polyoxyethylene castor oil may induce fatal allergic reactions in patients. Therefore, in order to prevent allergic reactions, patients need to be pretreated with large doses of ant...

Claims

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