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Nasal composition for resisting allergy and preventing PM2.5 in air as well as preparation method and application of nasal composition

A composition and anti-allergic technology, which is applied in the field of medical supplies, can solve the problems of inability to prevent inhalable particulate matter, difficult protection of PM2.5, and barrier effect to be improved, so as to achieve improved moisturizing and protective effects, high safety, and surface tension small effect

Inactive Publication Date: 2017-05-31
JIANG SU PHARMAMAXCORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN104546911A discloses a nasal allergen blocker, which is composed of petrolatum and rheology modifier, and its blocking effect needs to be improved
However, ordinary masks cannot prevent inhalable particulate matter, and medical masks are mainly aimed at respirable particulate matter above PM3
And it is difficult to protect PM2.5 by wearing a mask for a long time

Method used

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  • Nasal composition for resisting allergy and preventing PM2.5 in air as well as preparation method and application of nasal composition
  • Nasal composition for resisting allergy and preventing PM2.5 in air as well as preparation method and application of nasal composition
  • Nasal composition for resisting allergy and preventing PM2.5 in air as well as preparation method and application of nasal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The composition proportioning and preparation process of the present embodiment are as follows:

[0066]

[0067]

[0068] Preparation Process:

[0069] ① Add the weighed sodium pyruvate, polysorbate 80, pyrrolidone carboxylic acid, propylene glycol, simethicone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, disodium EDTA, and orange essence into the purified water, Stir well with a glass rod.

[0070] ② Slowly add cationic guar gum to the above mixed solution, and stir while adding.

[0071] ③ Use citric acid and sodium citrate to adjust the pH to 5-8;

[0072] ④Add water to 100g, stir well, and let stand to swell.

Embodiment 2

[0074] The composition proportioning and preparation process of the present embodiment are as follows:

[0075]

[0076]

[0077] Preparation Process:

[0078] ①Put half of the total amount of purified water required into a clean beaker, then add cationic guar gum, stir to disperse, let it stand for swelling, and then heat it in a water bath at 70°C for 30 minutes, stir fully while swelling, and then naturally cool down.

[0079] ②Add sodium pyruvate, polysorbate 20, polyethylene glycol stearate, glycerin, propylene glycol, simethicone, sodium benzoate, edetate disodium, and lemon essence to the other half of the total purified water required for purification water, stir thoroughly;

[0080] ③Mix the above ① and ② materials, then fully stir and disperse, and swell overnight.

[0081] ④ Use succinic acid and disodium succinate to adjust the pH to 5-8;

Embodiment 3

[0083] The composition proportioning and preparation process of the present embodiment are as follows:

[0084]

[0085] Preparation Process:

[0086] ①Mix sodium pyruvate, polyethylene glycol stearate, glycerin, propylene glycol, simethicone, methyl paraben, propyl paraben, polysorbate 80, and lemon essence, and heat to 50~70℃ to make the system uniform.

[0087] ② Add edetate disodium into purified water, stir evenly to dissolve it completely.

[0088] ③ Add cationic guar gum to ①, stir to disperse.

[0089] ④Use the homogenizer to homogenize the solution of ②, then add ③ into ②, and homogenize while adding. Use a pH regulator to adjust the pH to 5-8, add purified water to 100 g, and continue stirring until uniform.

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Abstract

The invention relates to a nasal composition for resisting allergy and preventing PM2.5 in air as well as a preparation method and an application of the nasal composition. The composition consists of a gel, a cell nutrient, a metal ion chelating agent and a pH buffer agent; and with the application of the composition, a transparent thin film is rapidly formed around nostrils. The gel accounts for 0.01-10 parts by weight, preferably 1-5 parts by weight and more preferably 1-3 parts by weight; the cell nutrient accounts for 0.01-5 parts by weight, preferably 0.2-1 part by weight and more preferably 0.5-1 part by weight; the metal ion chelating agent accounts for 0.005-2 parts by weight, and preferably 0.1-1 part by weight; and by virtue of the pH buffer agent, pH value is regulated to 5-8. The nasal composition provided by the invention, through a physical adsorption effect, can effectively block off effects of inhaled allergens on human body; and PM2.5 particles in the air can be effectively prevented from entering such respiratory systems as nasal passages, lung and the like.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to an anti-allergic and anti-PM2.5 nasal composition and a preparation method thereof. Background technique [0002] Allergies are common and are usually caused by inhaling or ingesting an allergen. Common allergens include inhalant allergens, food allergens, and contact objects. Clinical data show that inhaled allergens are the main factors causing allergic rhinitis, including pollen, dust mites, dust, feathers, cotton wadding, animal hair, fungi, etc. Allergic rhinitis can be divided into perennial and seasonal types, which can appear alone or in a mixed form with seasonal exacerbations. Symptoms and signs vary depending on the causative agent (eg, tree, grass, or pollen) and seasonality. Regional differences also play a role in the density and distribution of seasonal inhalant allergens. Perennial allergic rhinitis refers to the chronic reaction of the bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K31/19A61P11/02A61P37/08A61P39/00
CPCA61K9/06A61K9/0043A61K31/19A61K47/36
Inventor 蒋志君汪磊陆小娟
Owner JIANG SU PHARMAMAXCORP
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