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Application of anthocyanin in preparation of medicine for treating malaria

A technology for treating malaria and anthocyanins, applied in the field of medicine, can solve problems such as the antimalarial effect of anthocyanins that have not yet been seen

Inactive Publication Date: 2017-05-31
GUANGDONG XTEM BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report that anthocyanins have antimalarial effects

Method used

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  • Application of anthocyanin in preparation of medicine for treating malaria
  • Application of anthocyanin in preparation of medicine for treating malaria
  • Application of anthocyanin in preparation of medicine for treating malaria

Examples

Experimental program
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Effect test

Embodiment

[0019] Example: Determination of Antimalarial Activity of Anthocyanins and Chlorinated Anthocyanins in Vitro

[0020] Chlorinated anthocyanins and anthocyanins (from Shanghai Liding Biological). Antimalarial activity can be determined by measuring the content of Plasmodium dsDNA (Corey, V.C., et al., A broad analysis of resistance development in the malaria parasite. Nat Commun, 2016.7: p.11901.). Add erythrocyte suspension (100 μL, in RPMI 1640) infected with 3D7 strain P. Add 5g / L AlbuMAX (Gibco) and 50mg / L Gentamicin (Sigma) to the culture medium (Gibco) to make the malarial parasitemia reach 0.5% and the hematocrit reach 2%), then place at 37°C for 5 %CO2 incubator for 48 hours. Cells were lysed with lysate (Tris 2.4g / L, EDTA 1.86g / L, Saponin 0.08g / L, TritonX-100 0.8mL / L) from Sigma, and the dsDNA content was determined with 10000X SYBR GreenI reagent (Invitrogen). The determination procedure refers to the literature (Plouffe, D., et al., In silico activity profiling re...

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Abstract

The invention provides an application of anthocyanin in preparation of a medicine for treating malaria. The anthocyanin has a structural formula shown in the description. The invention also provides a medicinal composition containing the anthocyanin, a salt compound thereof and a pharmaceutically acceptable carrier. The weight percentage of the active ingredient namely the anthocyanin in the medicinal composition is 5-95%. By virtue of in vitro anti-malarial activity determination, a result shows that the anthocyanin and the salt compound thereof have good in vitro anti-malarial protozoan activity. Therefore, the anthocyanin can be used for preparing the medicine for treating malaria, and has a great clinical application value.

Description

technical field [0001] The present invention relates to medicine, in particular to the application of compound anthocyanin in the preparation of medicine for treating malaria, especially the application of compound anthocyanin in the preparation of medicine for treating malaria caused by Plasmodium. Background technique [0002] Malaria is an important parasitic disease that seriously endangers human health and life safety and affects social and economic development. Together with AIDS and tuberculosis, malaria is listed by the World Health Organization as a global public health problem that needs to be controlled urgently. According to the World Health Organization, in 2015 alone, there were 438,000 malaria deaths worldwide, and the vast majority occurred in children under the age of five in sub-Saharan Africa. Malaria is caused by Plasmodium, which includes Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale, among which Plasmodium falciparum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P33/06
CPCA61K31/352Y02A50/30
Inventor 单磊刘裕婷周宝珠乔志平
Owner GUANGDONG XTEM BIOTECH CO LTD
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