Guaifenesin and Dextromethorphan sustained release tablets and preparation method thereof

A technology of sustained-release tablets and guaiacol glycerin, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, pill delivery, etc., can solve the problems that patients cannot take medicine on time, the half-life is short, and affects the curative effect. Bioavailability, ease of administration, and effect of reducing the number of doses

Inactive Publication Date: 2017-05-31
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the half-life of guaiacol is short, and it needs to be taken 3 to 4 times a day, which brings great inconvenience to patients. Patients often fail to take the medicine on time or even miss it, which affects the curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A sort of Yumei Sustained Release Tablets are prepared from the following raw materials in parts by weight: 800 parts of guaiacol glyceryl ether, 60 parts of dextromethorphan hydrobromide, 1-10 parts of micropowder silica gel, 10-100 parts of hypromellose parts, 1-10 parts of magnesium stearate.

Embodiment 2

[0020] The hypromellose model can be one or more of HPMC100, HPMC15000, HPMC100000.

Embodiment 3

[0022] A Yumei sustained-release tablet and a preparation method thereof, the specific steps of the preparation method are:

[0023] Step 1, material preparation: Glycerin guaiacol and dextromethorphan hydrobromide were respectively pulverized, passed through a 100-mesh sieve, and set aside;

[0024] Step 2: Total mixing: Put guaiacol, dextromethorphan hydrobromide, micronized silica gel, and hypromellose into a three-dimensional motion mixer and mix for 30 minutes, then take it out for later use;

[0025] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into a wet granulator, add a suitable binder to obtain a suitable soft material, add it into a swing granulator to granulate, and dry;

[0026] Step 4: Total blending: Put the prepared granules into a three-dimensional motion mixer, and add the lubricant magnesium stearate, blend for 30 minutes, and discharge for later use;

[0027] Step 5: Tablet compression: Tablet compression with a...

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PUM

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Abstract

The invention discloses Guaifenesin and Dextromethorphan sustained release tablets and a preparation method thereof. The Guaifenesin and Dextromethorphan sustained release tablets are composed of dextromethorphan hydrobromide and guaifenesin. The guaifenesin is a phlegm-expelling agent, and is capable of reflexively promoting increase of respiratory tract gland secretion by stimulating gastric mucosa to cause slight nausea, phlegm is diluted and coughed up; dextromethorphan hydrobromide is a central antitussive agent, has detect effect on coughing center of medulla oblongata, can inhibit cough reaction, and generates no addition. The Guaifenesin and Dextromethorphan sustained release tablets are used for treating cough and expectoration due to upper respiratory infection and bronchitis; compared with various same kinds of the product, the Guaifenesin and Dextromethorphan sustained release tablets have dual efficacies of eliminating phlegm and relieving cough, has the advantages of definite therapeutic effect, stable quality, and convenient administration, and is an ideal selection for medicine capable of relieving cough and resolving phlegm.

Description

technical field [0001] The present invention relates to the field of chemical drug sustained-release preparations, especially A sort of Yumei sustained-release tablet and its preparation method. Background technique [0002] Yumei Sustained-release Tablets are sustained-release preparations, the main components of which are dextromethorphan hydrobromide and guaiacol. This product is composed of the non-addictive antitussive drug dextromethorphan hydrobromide and the expectorant drug guaiacol. Dextromethorphan hydrobromide is a non-dependent central antitussive drug, which directly inhibits the medulla cough center and exerts an antitussive effect. It is an antitussive drug designated by the World Health Organization to replace codeine. It directly acts on medulla cough The central nervous system suppresses the cough response, is non-addictive, does not inhibit breathing, and has no drug resistance. Guaifenesin is a nauseous expectorant, which can stimulate the gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/22A61P11/14A61P11/00A61P11/10A61K31/09
CPCA61K31/485A61K9/2013A61K9/2054A61K31/09A61K2300/00
Inventor 马玉国张昕任萃文江延辉马凌风王海涛
Owner HARBIN SHENGJI PHARMA
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