A kind of Klebsiella pneumoniae phage and its application

A Klebsiella and bacteriophage technology, applied in the field of bioengineering, can solve the problems of limiting the application of bacteriophage, narrow lysis spectrum, etc., and achieve the effects of less toxic and side effects, strong killing activity and high safety
CN106754745BActive Publication Date: 2020-07-14JIANGSU ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU ACAD OF AGRI SCI
Publication Date
2020-07-14

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Abstract

The invention discloses a strong lysis bacteriophage for splitting NDM-1 positive Klebsiella pneumoniae clinical isolates, and an application of the strong lysis bacteriophage used as a biological preparation in the prevention and treatment of NDM-1 Klebsiella pneumoniae induced infection and pollution. The preservation number of the bacteriophage is CCTCC M 2015760, and the bacteriophage has a regularly icosahedral head and a telescopic tail, and belongs to a Myoviridae double-stranded DNA bacteriophage. The bacteriophage has strong kilign activity and wide bacteriophage lysis spectrum, can be used for preparing medicines for preventing and treating NDM-1 Klebsiella pneumoniae induced bacterium infection, and also can be used for killing NDM-1 positive Klebsiella pneumoniae in culture environment and medical environment.
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Description

technical field

[0001] The invention relates to the field of bioengineering, in particular to a Klebsiella pneumoniae phage vB_KpnM_he1 (klebsiella pneumoniae phage vB_KpnM_he1) and its application. Background technique

[0002] Klebsiella (Klebsiella) is a class of encapsulated Gram-negative bacilli in the Enterobacteriaceae, including Klebsiella pneumoniae (also known as Klebsiella pneumoniae), Klebsiella stinky nose and rhinosclerosis Klebsiella is closely related to humans, especially Klebsiella pneumoniae, which accounts for more than 95% of Klebsiella infections. It is an important pathogen of respiratory tract infection, often causing severe pneumonia, and can also It can cause serious diseases such as urinary tract infection, biliary tract infection, sepsis and suppurative meningitis.

[0003] Klebsiella pneumoniae (Klebsiella pneumoniae) is widely distributed in soil, water, agricultural and forest products in nature, and is also common in the intestinal tract and ...

Claims

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