Method for Enrichment and Detection of Trace Aristolochic Acid A from Longdan Xiegan Pills

A technology for gentian xiegan pills and aristolochic acid, which is applied to measurement devices, instruments, analytical materials, etc., can solve the problems of difficult elution, large loss of imprinted polymers, limited binding capacity, etc., and achieves a safe enrichment process. , The operation process is simple, and the effect of reducing toxic damage
CN106770784BActive Publication Date: 2019-06-28XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2019-06-28

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Abstract

The invention discloses a method for enriching and detecting trace aristolochic acid A in a traditional Chinese medicine bolus of gentian for purging liver-fire. The method comprises the following steps: firstly, activating silica gel; then modifying a surface of the silica gel; synthesizing a molecularly imprinted polymer on the surface of the silica gel; filling a column with the molecularly imprinted polymer; activating with methanol to obtain a molecularly imprinted solid phase extraction column; using the molecularly imprinted solid phase extraction column for detecting and enriching aristolochic acid A in the traditional Chinese medicine bolus of gentian for purging liver-fire. The method provided by the invention has advantages of simple operation, high binding capacity, high mass transfer rate and high enrichment efficiency.
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Description

technical field

[0001] The invention relates to the technical field of molecular imprinting, in particular to a method for enriching and detecting trace amounts of aristolochic acid A from Longdan Xiegan Pills, a Chinese patent medicine. Background technique

[0002] Aristolochic acid A is a class of nitrophenanthrene compounds, mainly found in plants of the genus Aristolochia and Asarum, which can cause severe nephrotoxicity. Medicinal plants and preparations containing aristolochic acids have been successively Banned in many countries. At present, some traditional Chinese medicines and related Chinese patent medicines are still in use, and the removal of aristolochic acid in Chinese medicines is beneficial to reduce the toxicity of Chinese medicines.

[0003] At present, there are two commonly used enrichment methods for aristolochic acid A: solvent method column separation method; solid phase extraction method, among the above enrichment methods for aristolochic acid A: ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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