A kind of povidone-iodine film-forming disinfectant and its preparation method and application

A technology of povidone-iodine and disinfectant, which is applied in the field of povidone-iodine film-forming disinfectant and its preparation, can solve problems such as poor solution stability, short product validity period, and decreased effective iodine content, and achieve solution fluidity And good film-forming properties, ensuring the stability of available iodine content, effective iodine content and pH stability

Active Publication Date: 2020-03-10
LUOYANG HUIZHONG ANIMAL MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of povidone-iodine solution on the market is often unstable, and the available iodine content drops rapidly, which directly affects its therapeutic effect
In clinical practice, povidone-iodine is mostly prepared and used first, which is very inconvenient to use, and the product has a short validity period, which not only cannot guarantee the quality, but also causes a lot of waste
In addition, currently existing povidone-iodine disinfectant (a kind of povidone-iodine gel disclosed as Chinese patent application CN102657600A) contains glycerol and pH buffers such as sodium dihydrogen phosphate and disodium hydrogen phosphate in the prescription, The product prepared according to this formula is easy to separate after being placed, and the available iodine content drops rapidly, and the solution stability is not good, thus affecting the use effect

Method used

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  • A kind of povidone-iodine film-forming disinfectant and its preparation method and application
  • A kind of povidone-iodine film-forming disinfectant and its preparation method and application
  • A kind of povidone-iodine film-forming disinfectant and its preparation method and application

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Embodiment approach

[0026] As a preferred embodiment of the present invention, the method of the present invention comprises the following steps:

[0027] (1) Preparation of carbomer mother liquor: Weigh an appropriate amount of carbomer and add it to a beaker filled with the required amount of purified water, slowly add carbomer while stirring the purified water, the process of adding carbomer should prevent agglomeration, After the preparation is completed, place it for 24 hours to swell evenly, then adjust the pH to 6.0-6.5 with NaOH solution, autoclave at 115°C for 30 minutes, and cool it for later use.

[0028] Preparation of PVP mother liquor: Weigh an appropriate amount of PVP and place it in a beaker filled with the required amount of purified water, stir evenly, and place it for 15 minutes. After the PVP is completely dissolved, the solution becomes a light yellow transparent liquid.

[0029] Prepare potassium iodate mother liquor: take a clean and dry beaker and place it in an electroni...

Embodiment 1

[0039] Embodiment 1 The preparation example of povidone-iodine film-forming disinfectant of the present invention

preparation example 1

[0040] Preparation Example 1 This preparation example povidone iodine film-forming disinfectant (per 1kg) comprises the following raw materials: povidone iodine: 50g, carbomer 934: 1g, PVP-K30: 10g, potassium iodate: 1g, percentage by weight They are: povidone-iodine: 5%, carbomer 934: 0.1%, PVP-K30: 1%, potassium iodate: 0.1%.

[0041] The preparation steps are as follows:

[0042] (1) Preparation of Carbomer 934 mother liquor: Weigh 1g of Carbomer 934 and add it to a beaker filled with 99g of purified water. Slowly add Carbomer while stirring the purified water. The process of adding Carbomer should prevent agglomeration. After the preparation is completed, place it for 24 hours to swell evenly, then adjust the pH to 6.0-6.5 with 4mol / L NaOH solution, autoclave at 115°C for 30 minutes, and cool it for later use;

[0043] Preparation of PVP-K30 mother liquor: Weigh 10g of PVP-K30 and place it in a beaker filled with 10g of purified water, stir evenly, and let it stand for 15...

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Abstract

The invention provides a povidone-iodine film-forming disinfectant, which comprises the following components by weight percentage: 5% of povidone-iodine, 0.1-0.5% of Carbomer, 1-10% of PVP and 0.1-0.5% of potassium iodate. The invention also discloses a preparation method and application of the povidone-iodine film-forming disinfectant. After long-term placement, the povidone-iodine film-forming disinfectant provided by the invention has a stable effective iodine content and pH, and is free of layering after long-time placement, the solution has good liquidity, and can form a layer of disinfectant protective film capable of disappear spontaneously, and can effectively prevent cow mastitis.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and in particular relates to a povidone-iodine film-forming disinfectant and a preparation method and application thereof. Background technique [0002] Mastitis is one of the three major diseases of dairy cows. The incidence of mastitis in dairy cows in my country is as high as 20-60%. It can reduce milk production and milk quality of dairy cows, not only increase treatment costs, but may also cause waste milk. Estrus and pregnancy of dairy cows; some sick cows are forced to be eliminated due to a significant reduction in milk production or loss of lactation ability, so mastitis is one of the important reasons for the economic loss of dairy cow production. There are three key factors in the occurrence of mastitis, one is the source of infection, the other is the route of transmission, and the third is the susceptible animal. In most cases, the udder infection of dairy cows...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/79A61K9/08A61K47/32A61K47/04A61P29/00A61P15/14A61P31/02A61P31/04
CPCA61K9/08A61K31/79A61K47/02A61K47/32
Inventor 张许科刘兴金李朋朋
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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