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Oral dosage form

A preparation, tablet technology, applied in the production of the composition, mucoadhesive dosage form, attenuated probiotics, prepared mucoadhesive ingredients are fixed to the oral cavity, a system for testing the mucoadhesive properties of the dosage form, oral cavity Dispersible tablets, which maintain a sufficient amount of probiotics, can deliver active substances in the oral cavity, and can solve the problems of no company reporting relevant information and research progress

Active Publication Date: 2017-06-13
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for probiotic preparations for long-term release in the oral cavity, few companies have reported relevant information and research progress

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] Preparation of mucoadhesive orodispersible tablets containing granules of a mucoadhesive (Metolose 65SH50) probiotic (Lactobacillus plantarum 299V)

[0128] Preparation of mucoadhesive probiotic particles. First screen Lactobacillus plantarum 299V Particles >200 μm in diameter are removed. will then be sieved and Metolose 65SH50 were added to the Turbula mixer and mixed at 30 rpm for 5 minutes after adding the desiccant bag to obtain a dry homogeneous mixture, which was then transferred to a Somakon experimental mixer and adjusted to 20 ° C under the passage of dry nitrogen. Add 5 ml of Eudragit L isopropanol solution (12.5%) to the mixture with stirring at 280 rpm, then stir the wetted mixture with a scraper for 1 minute, and finally dissolve the remaining Eudragit L isopropanol solution with stirring at 330 rpm. join in. Wet granules were formed after stirring with a scraper at 370 rpm for 2 minutes and sieved through a 710 μm sieve, then placed in a desiccator ...

Embodiment 2

[0135] Preparation of mucoadhesive orodispersible tablets containing granules of a mucoadhesive (Metolose 65SH50) probiotic (Lactobacillus paracasei 8700:2)

[0136] The preparation steps were as in Example 1, but the bacterial powder was not sieved before granulation. The amounts of various materials used are listed in Table 2.

[0137] Table 2: Tablet Composition

[0138]

[0139] The mucoadhesive orodispersible tablet Ex2 was obtained in Example 2 and the tablet characterization data are listed in Table 4.

Embodiment 3

[0143] Preparation of Mucoadhesive Orodispersible Tablets Containing Granules of Mucoadhesive (Food Grade Chitosan) Probiotic (Lactobacillus paracasei 8700:2)

[0144] The preparation steps were as in Example 1, but the bacterial powder was not sieved before granulation. The amounts of various materials used are listed in Table 3.

[0145] Table 3: Tablet Composition

[0146]

[0147]

[0148] In Example 3, the mucoadhesive orodispersible tablet Ex3 was obtained and the tablet characterization data are listed in Table 4.

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Abstract

The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

Description

[0001] technical background [0002] The present invention belongs to the field of delivering active substances to the oral cavity and relates to mucoadhesive active compositions and corresponding mucoadhesive dosage forms which can deliver active substances in the oral cavity, in particular orodispersible tablets for delivering probiotic substances. The invention also relates to a method of producing said composition and a method of processing said composition into mucoadhesive dosage forms, especially orodispersible tablets. Furthermore the present invention relates to a system and method for testing the mucoadhesive properties of dosage forms. [0003] current technology [0004] Oral administration is the method of swallowing an active substance to release it into the gastrointestinal (GI) tract of humans and animals. The gastrointestinal tract mainly includes the stomach, small intestine, and large intestine. Oral delivery is the most commonly used method in the pharmace...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/16A61K35/741A61K47/32A61K47/38A61K47/36G01N19/04
CPCA61K9/0056A61K9/1635A61K9/1652A61K9/2027A61K9/2054A61K35/741G01N19/04A61K9/006A61K9/19A61K9/205A61K9/2063A61K9/2009A61K9/2018A61K35/747A61K2035/115G01N33/5088A61K9/2013A61K2300/00A61K47/32A61K47/38A61K9/2045A61K9/2059A61K9/2068A61K9/2095
Inventor 罗尔夫·丹尼尔斯安雅·霍夫曼马库斯·鲁道夫·格茨约尔格·蒂洛·费舍尔克斯廷·霍姆格伦
Owner SYMRISE GMBH & CO KG
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