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Novel use of a compound and its preparation method

A technology of compounds and uses, applied in the field of medicinal chemistry, to achieve the effect of inhibiting lung cancer cells, inhibiting cancer cells, and improving the purity of separation and purification

Inactive Publication Date: 2019-12-06
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there have been no reports about the application of the above-mentioned compounds in the field of cancer treatment, and they have not been developed and applied to clinical treatment of cancer, especially in the treatment of lung cancer. The effect is remarkable, for this reason, the present invention proposes a kind of new application of above-mentioned compound in the preparation of anticancer drug and preparation method thereof

Method used

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  • Novel use of a compound and its preparation method
  • Novel use of a compound and its preparation method
  • Novel use of a compound and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation method of the compound represented by formula (I) described in this embodiment includes the following steps:

[0047]

[0048] (1) Take 10kg of dried whole plant of Baiying, put it in a reflux bottle, add 80L of ethanol aqueous solution with a volume concentration of 70%, reflux and extract 3 times at 100℃, extract 2 hours each time, and carry out the obtained alcohol extract Filter, combine the resulting filtrate and concentrate it under reduced pressure to an extract with a relative density of 1.05 (measured at 50°C). Add 10 times the mass of the extract to the extract for dispersion, filter, and add the resulting filtrate to D151 Ion exchange macroporous adsorption resin column, and then eluted by 3 times the column volume of distilled water, 3 times the column volume of 95% ethanol aqueous solution, discarded the eluate, and then passed 4 times the column volume containing volume The hydrochloric acid with a concentration of 6‰ is eluted with a 95% etha...

Embodiment 2

[0060] The preparation method of the compound represented by formula (I) described in this embodiment includes the following steps:

[0061] (1) Take 10kg of dried whole plant of Baiying, put it in a reflux bottle, add 60L of ethanol solution with a volume concentration of 65%, reflux and extract twice at 90℃, extract 4 hours each time, and extract the obtained alcohol extract Filter, combine the resulting filtrate and concentrate it under reduced pressure to an extract with a relative density of 1.05 (measured at 50°C). Add 8 times the mass of the extract to the extract for dispersion, filter, and add the resulting filtrate to the extract. D151 ion exchange macroporous adsorption resin column, and then eluted with 2 column volumes of distilled water, 4 column volumes of ethanol solution with a volume concentration of 93%, discarded the eluent, and then passed 3 column volumes containing The volume concentration of hydrochloric acid is 7‰, and the volume concentration of hydrochl...

Embodiment 3

[0067] The preparation method of the compound represented by formula (I) described in this embodiment includes the following steps:

[0068] (1) Take 10kg of dried whole plant of Baiying and place it in a reflux bottle, add 100L of ethanol solution with a volume concentration of 75%, reflux and extract 3 times at 110°C, extract 2 hours each time, and combine the obtained alcohol extract Filter, combine the obtained filtrate and concentrate it under reduced pressure to an extract with a relative density of 1.05 (measured at 50°C). Add 12 times the mass of the extract to the extract for dispersion, filter, and add the obtained filtrate to the extract. D151 ion exchange macroporous adsorption resin column, and then eluted by 4 times the column volume of distilled water, 2 times the column volume of the ethanol solution with a volume concentration of 97%, discarded the eluate, and then passed 5 times the column volume containing The volume concentration of hydrochloric acid is 5‰, an...

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Abstract

The invention belongs to the field of medicinal chemistry, and particularly relates to a new use and preparation method of a compound, namely the new use and preparation method of (3beta,5alpha,22alpha,25R)-spirosolane-3-O-beta-D-glucopyranosyl-(1->2)-O-[beta-D-xylopyranose-(1->3)]-O-beta-D-glucopyranosyl-(1->4)-beta-D-pyran galactoside; the compound can inhibit lung cancer cells, makes the growth period of the lung cancer cells arrested in the early stage and promotes apoptosis of the lung cancer cells. Therefore, the compound can be used in preparation of anticancer drugs, especially in preparation of anti-lung cancer drugs.

Description

Technical field [0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a new use of a compound and a preparation method thereof, namely (3β,5α,22α,25R)-spirostaline-3-O-β-D-glucopyranosyl-( 1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl New uses of glycosides and their preparation methods. Background technique [0002] (3β,5α,22α,25R)-Spirolostaline-3-O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→ 3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside, CAS: 90366-11-3, white powder, soluble in methanol, insoluble in ethanol , Water, the structural formula is as follows: [0003] [0004] (3β,5α,22α,25R)-Spirolostaline-3-O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→ 3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside can be derived from Baiying (the dried whole plant of Solanum lyratum Thunb) Extracted in. However, there is no report on the application of the above-mentioned compounds in the tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/706C07J71/00A61P35/00
CPCA61K31/706C07J71/0005
Inventor 王建农韩林
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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