Novel use of a compound and its preparation method

A technology of compounds and uses, applied in the field of medicinal chemistry, to achieve the effect of inhibiting lung cancer cells, inhibiting cancer cells, and improving the purity of separation and purification
CN106822167BInactive Publication Date: 2019-12-06XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
Publication Date
2019-12-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of medicinal chemistry, and particularly relates to a new use and preparation method of a compound, namely the new use and preparation method of (3beta,5alpha,22alpha,25R)-spirosolane-3-O-beta-D-glucopyranosyl-(1->2)-O-[beta-D-xylopyranose-(1->3)]-O-beta-D-glucopyranosyl-(1->4)-beta-D-pyran galactoside; the compound can inhibit lung cancer cells, makes the growth period of the lung cancer cells arrested in the early stage and promotes apoptosis of the lung cancer cells. Therefore, the compound can be used in preparation of anticancer drugs, especially in preparation of anti-lung cancer drugs.
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Description

Technical field

[0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a new use of a compound and a preparation method thereof, namely (3β,5α,22α,25R)-spirostaline-3-O-β-D-glucopyranosyl-( 1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl New uses of glycosides and their preparation methods. Background technique

[0002] (3β,5α,22α,25R)-Spirolostaline-3-O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→ 3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside, CAS: 90366-11-3, white powder, soluble in methanol, insoluble in ethanol , Water, the structural formula is as follows:

[0003]

[0004] (3β,5α,22α,25R)-Spirolostaline-3-O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→ 3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside can be derived from Baiying (the dried whole plant of Solanum lyratum Thunb) Extracted in. However, there is no report on the application of the above-mentioned compounds in the tre...

Claims

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