Complex, its preparation method and hydrogel
A technology of complexes and hydrogels, which can be used in pharmaceutical formulations, active ingredients of heavy metal compounds, non-active ingredients of polymer compounds, etc., and can solve problems such as large side effects, psychological and physical harm to patients, etc.
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[0048] Correspondingly, the present invention provides a kind of preparation method of complex, comprises the following steps:
[0049] The drug reacts with the polymer having the structure of formula (I) or formula (II) in an aqueous medium to form a complex;
[0050]
[0051] where the R 1 Independently selected from -CH 2 -, -(CH 2 ) 2 ; 2 independently selected from H ions, metal cations or organic cations;
[0052] m is the degree of polymerization, 10≤m≤227, preferably 20≤m≤185, more preferably 30≤m≤115;
[0053] n is the degree of polymerization, 10≤n≤226; preferably 20≤n≤180, more preferably 30≤n≤112;
[0054] x is the degree of polymerization, 1≤x≤100; preferably 5≤x≤80; more preferably 3≤x≤50;
[0055] y is the degree of polymerization, 1≤y≤50; preferably 2≤y≤40; more preferably 3≤y≤30;
[0056] p is the degree of polymerization, 2≤p≤50; preferably 2≤p≤40; more preferably 3≤p≤30;
[0057] q is the degree of polymerization, 2≤q≤50; preferably 2≤q≤40; more ...
Embodiment 1
[0126] Azeotrope 6.0 g of aminated polyethylene glycol monomethyl ether with a number average molecular weight of 2000 and 200 mL of toluene at 130 ° C for 3 h to remove water, then vacuum the remaining toluene to dryness; dissolve the obtained solid in 100 mL In dried N,N-dimethylformamide, the first solution was obtained; 9.0 g of γ-ethyl-L-glutamic acid ester-N-carboxylic acid internal anhydride and 4.75 g of γ-benzyl-L-glutamine Amino acid ester-N-carboxylic acid internal acid anhydride was dissolved in 160mL of dry N,N-dimethylformamide to obtain a second solution; in a nitrogen atmosphere, the first solution was mixed with the second solution, at room temperature , stirring and reacting for 80 hours under the protection of nitrogen; after the reaction, drain N,N-dimethylformamide under reduced pressure, then dissolve the obtained solid in chloroform, settle with ether, filter with suction, and dry to obtain Polyethylene glycol monomethyl ether-polyamino acid ester block ...
Embodiment 2
[0129] Azeotrope 3.1 g of aminated polyethylene glycol monomethyl ether with a number average molecular weight of 2000 and 100 mL of toluene at 120 ° C for 3 h to remove water, and then drain the remaining toluene under reduced pressure; dissolve the obtained solid in 30 mL In dried N,N-dimethylformamide, the first solution was obtained; 4.7g of γ-ethyl-L-glutamic acid ester-N-carboxylate and 1.2g of γ-benzyl-L-glutamine Amino acid ester-N-carboxylic acid internal acid anhydride was dissolved in 62mL of dry N,N-dimethylformamide to obtain a second solution; in a nitrogen atmosphere, the first solution was mixed with the second solution, at room temperature , stirring and reacting for 70 hours under nitrogen protection; after the reaction, drain N,N-dimethylformamide under reduced pressure, then dissolve the obtained solid in chloroform, settle with ether, filter with suction, and dry to obtain Polyethylene glycol monomethyl ether-polyamino acid ester block polymer. Undeprotec...
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