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Hypoglycemic pharmaceutical composition and its preparation method, preparation and application

A composition and drug technology, applied in the field of medicine, can solve the problems of lack of treatment for the cause, difficult to keep, urgent and the like, and achieve the effects of no toxic side effects, easy portability, and reducing the occurrence of diabetes

Inactive Publication Date: 2017-07-25
杨本雷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The etiology and pathogenesis of diabetes have not yet been fully understood, and there is a lack of treatment for the cause. At present, oral hypoglycemic drugs and insulin injections are the two main means of diabetes treatment. Insulin treatment resistance occurs from time to time, and it is inconvenient to carry and keep. Therefore, it is urgent to find new drug preparations for the treatment of diabetes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of the hypoglycemic pharmaceutical composition of the present invention includes pre-treatment, extraction and post-treatment steps, specifically including:

[0025] A. Select and wash the raw materials, then weigh the raw materials according to the formula ratio and mix them to obtain material a for use;

[0026] B. Add ethanol solution to material a and soak for 7-10 days, filter to obtain filtrate b and filter residue c;

[0027] C. Adding 8-12 times the weight of the filter residue c to the filter residue c and boiling it for 3 to 4 times for 0.5 to 1.5 hours each time, combine the filtrate and concentrate to obtain a thick paste d;

[0028] D. Concentrate the filtrate b to obtain a thick ointment e, mix the thick ointment d and the thick ointment e uniformly, dry, pulverize, and sieve to obtain the target hypoglycemic pharmaceutical composition.

[0029] The volume percentage concentration of the ethanol solution in step B is 60-80%.

[0030] The volume...

Embodiment 1

[0043] Take 100g of raw pueraria lobata, 50g of asparagus, and 50g of burdock seeds, add 5 times the total weight of the raw materials to an 80% ethanol solution by volume, soak for 10 days at a temperature of 20°C, filter to obtain filtrate and filter residue, and concentrate the filtrate to obtain a thick Paste e; add 12 times the filter residue to the filter residue and boil it 4 times for 1 hour each time, filter, collect the filtrate, and concentrate to obtain thick paste d, mix thick paste d and thick paste e evenly and pulverize through a 200 mesh sieve to obtain the target Hypoglycemic pharmaceutical composition.

Embodiment 2

[0045] Take 300g of the raw materials Pueraria lobata, 250g of asparagus, and 150g of burdock seeds, add 3 times the total weight of the raw materials to a 60% ethanol solution, soak at a temperature of 40°C for 10 days, filter to obtain filtrate and filter residue, and concentrate the filtrate to obtain a thick Paste e; add 8 times the filter residue to the filter residue and cook for 3 times, 1 hour each time, filter, collect the filtrate, concentrate to obtain thick paste d, mix thick paste d and thick paste e evenly and pulverize through 200 mesh sieve to obtain the target Hypoglycemic pharmaceutical composition.

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PUM

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Abstract

The invention discloses a hypoglycemic pharmaceutical composition and its preparation method, preparation and application. The hypoglycemic pharmaceutical composition comprises, by weight, 100 to 300 parts of pachyrhizua angulatus, 50 to 250 portions of radix asparagi and 50 to 150 portions of fructus arctii. The hypoglycemic pharmaceutical composition is prepared by pretreatment, extraction and post-treatment. The preparation of the hypoglycemic pharmaceutical composition is a tablet, powder, a capsule, a granule or a pill containing the hypoglycemic pharmaceutical composition and pharmaceutically acceptable accessories. The invention discloses a use of the hypoglycemic pharmaceutical composition in preparation of a hypoglycemic drug. The raw drugs are combined and produce synergism so that the hypoglycemic pharmaceutical composition has effects of clearing heat and moistening dryness, and nourishing yin and generating body fluid, and can be used for clinical treatment on diabetes.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a hypoglycemic pharmaceutical composition and a preparation method, preparation and application thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by increased chronic blood glucose (blood sugar) levels. Hyperglycemia is caused by defects in insulin secretion and / or insulin action. In addition to carbohydrates, there are also abnormal protein and fat metabolism. Chronic illness can cause damage to multiple organs and multiple systems, leading to chronic progressive diseases of the eyes, kidneys, nerves, heart, blood vessels and other tissues, causing functional defects and failure. Acute metabolic disorders such as ketoacidosis and hyperosmolar coma can occur in severe illness or stress. This disease reduces the quality of life of patients, shortens life span, and increases mortality. [0003] Diabetes is a common and frequentl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61P3/10
CPCA61K36/488A61K36/28A61K36/8965A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 杨本雷杨舒雅
Owner 杨本雷
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