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Application of 17-alpha hydroxyprogesterone compound in preventing and treating inflammatory disease of neutrophil

A technology of neutrophils and α-hydroxyprogesterone, which is applied in the field of pharmacotherapeutics, can solve the problems of inability to prevent the progression and deterioration of chronic obstructive pulmonary disease, such as lung function decline

Inactive Publication Date: 2017-08-01
上海普瑞得生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bronchodilators and glucocorticoids currently on the market can only treat the downstream effects of inflammation, which can slightly improve CODP lung function, improve the quality of life and exacerbation rate, but they cannot prevent the progression and deterioration of COPD and the continuous decline in lung function

Method used

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  • Application of 17-alpha hydroxyprogesterone compound in preventing and treating inflammatory disease of neutrophil
  • Application of 17-alpha hydroxyprogesterone compound in preventing and treating inflammatory disease of neutrophil
  • Application of 17-alpha hydroxyprogesterone compound in preventing and treating inflammatory disease of neutrophil

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Embodiment Construction

[0069] After extensive and in-depth research, the inventors of the present application discovered for the first time that 17-α hydroxyprogesterone alone, or combined administration of 17-α hydroxyprogesterone and glucocorticoids can be very effective in the prevention and treatment of neutrophil inflammatory diseases . Experiments have shown that 17-α hydroxyprogesterone can significantly reduce the number and infiltration of biological neutrophils in the blood and respiratory tract, inhibit neutrophil pneumonia, and inhibit interleukins / pro-inflammatory cytokines in the respiratory tract and lungs. The present invention has been accomplished on this basis.

[0070] the term

[0071] As used herein, the term "BALF" refers to bronchoalveolar lavage fluid.

[0072] As used herein, the term "granulocytosis-type respiratory disease" refers to various respiratory diseases (such as COPD, asthma, etc.) characterized by granulocytosis. For example, in COPD, neutrophils are among th...

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Abstract

The invention provides medicine compositions containing 17-alpha hydroxyprogesterone and application of the medicine compositions, in particular to a medicine composition containing the active ingredient of 17-alpha hydroxyprogesterone, and a medicine composition containing active ingredients of the 17-alpha hydroxyprogesterone and glucocorticoid. Found by study, the 17-alpha hydroxyprogesterone can obviously reduce the number and infiltration of biologic neutrophil in blood and respiratory tract, the lung inflammation of neutrophilic granulocyte is inhibited, and respiratory tract and lung interleukin / proinflammatory cytokines re ainhibited; by singly applying the 17-alpha hydroxyprogesterone, or jointly applying the 17-alpha hydroxyprogesterone and the glucocorticoid, the inflammatory disease of neutrophil can be very effectively prevented and treated.

Description

technical field [0001] The invention relates to the field of drug therapy, in particular to the medical application of 17-alpha hydroxyprogesterone compound in the prevention and / or treatment of neutrophil inflammatory diseases. Background technique [0002] Neutrophils are involved in various acute and chronic inflammatory diseases. The release of various pro-inflammatory mediators leads to neutrophil adhesion and activation. Activated neutrophils degranulate and release cytokines leading to an inflammatory response. If the inflammation cannot be resolved, neutrophil apoptosis or phagocytosis is dysregulated, neutrophil activation is poorly controlled, resulting in persistent cell infiltration, persistent inflammatory response, tissue damage destruction and various autoimmune diseases and chronic inflammation. disease. [0003] In the treatment of respiratory diseases such as chronic obstructive pulmonary disease, emphysema, asthma, acute lung injury, acute respiratory d...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61K45/00A61P29/00A61P11/06A61P11/00A61P1/00A61P1/04A61P1/12A61P37/02A61P19/02A61P25/00A61P9/00A61P19/06A61P13/12A61P15/00A61P9/10C12N5/0787
CPCA61K31/57A61K45/00C12N5/0642C12N2501/00A61K2300/00
Inventor 栾翰森张旻李长青杜涛费霞张鹏宇周新
Owner 上海普瑞得生物技术有限公司
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