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Lisinopril compound preparation for treating cardiovascular disease and preparation method thereof

A compound preparation and cardiovascular technology, which is applied in the field of compound preparations for the treatment of cardiovascular diseases, can solve the problems of poor patient compliance, low blood pressure control rate, and non-optimized ratio, and achieve quick results, high blood pressure rate, and The effect of reducing adverse reactions

Inactive Publication Date: 2017-08-11
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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  • Lisinopril compound preparation for treating cardiovascular disease and preparation method thereof

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Effect test

Embodiment 1

[0029] The invention provides a lisinopril compound preparation for treating cardiovascular diseases, which comprises the following medicines in parts by weight: 3.5 parts of lisinopril, 1.6 parts of hydrochlorothiazide and 2.52 parts of levamlodipine besylate.

[0030] The present invention also provides a preparation method of the lisinopril compound preparation for treating cardiovascular diseases, comprising the following steps:

[0031] (1) After mixing lisinopril, hydrochlorothiazide and levamlodipine besylate uniformly in proportion, sieve 200 mesh to obtain mixed powder 1;

[0032] (2) Mix powder 1 with sucrose, glycyrrhizin, polyethylene glycol, gum arabic, arabinogalactan, castor oil, glycerin, castor oil, micropowder silica gel, precrossed starch, propyl gallate, sulfur dioxide After mixing uniformly in water, dry and sieve 80 mesh to obtain mixed powder 2;

[0033] (3) After the mixed powder 2 is packaged, the lisinopril compound preparation for treating cardiovas...

Embodiment 2

[0035] The invention provides a lisinopril compound preparation for treating cardiovascular diseases, which comprises the following medicines in parts by weight: 4.2 parts of lisinopril, 2.38 parts of hydrochlorothiazide and 2.8 parts of levamlodipine besylate.

[0036] The present invention also provides a preparation method of the lisinopril compound preparation for treating cardiovascular diseases, comprising the following steps:

[0037] (1) After mixing lisinopril, hydrochlorothiazide and levamlodipine besylate uniformly in proportion, sieve 200 mesh to obtain mixed powder 1;

[0038] (2) mix powder 1 with aspartame, polyethylene glycol, hydroxypropyl methylcellulose, castor oil, micronized silica gel, precrossed starch, dibutylhydroxytoluene, and propyl p-hydroxybenzoate After mixing evenly in physiological saline, dry and sieve 80 mesh to obtain mixed powder 2;

[0039] (3) After the mixed powder 2 is packaged, the lisinopril compound preparation for treating cardiovas...

Embodiment 3

[0041] The invention provides a lisinopril compound preparation for treating cardiovascular diseases, which comprises the following medicines in parts by weight: 3 parts of lisinopril, 1 part of hydrochlorothiazide, and 2.4 parts of levamlodipine besylate.

[0042] The present invention also provides a preparation method of the lisinopril compound preparation for treating cardiovascular diseases, comprising the following steps:

[0043] (1) After mixing lisinopril, hydrochlorothiazide and levamlodipine besylate uniformly in proportion, sieve 200 mesh to obtain mixed powder 1;

[0044] (2) Mix the mixed powder 1 with citric acid, polyvinylpyrrolidone, hydroxypropyl cellulose, castor oil, micronized silica gel, precrossified starch, butylhydroxyanisole, and lactis in a solvent, and then dry it. Sieve through 80 mesh to obtain mixed powder 2;

[0045] (3) After the mixed powder 2 is packaged, the lisinopril compound preparation for treating cardiovascular diseases is prepared.

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Abstract

The invention relates to a compound preparation for treating cardiovascular disease and in particular relates to a lisinopril compound preparation for treating cardiovascular disease. The lisinopril compound preparation comprises the following drugs in parts by weight: 2-6 parts of lisinopril, 0.8-2.8 parts of hydrochlorothiazide and 1.6-3.6 parts of levamlodipine besylate. According to an acting mechanism of giving full play to complementation of drugs by combined medication, the curative effect is increased, and the standard is quickly achieved, the rate of reaching the standard of blood pressure reaches 82%, and adverse effects related to increase of some dosage are reduced. The compound preparation has the characteristics of being quick to take effect, high in rate of reaching the standard of blood pressure, small in side effect and low in cost.

Description

technical field [0001] The invention relates to a compound preparation for treating cardiovascular diseases, in particular to a compound preparation of lisinopril for treating cardiovascular diseases. Background technique [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin Ⅱ receptor blockers (ARBs), etc., lisinopril is the drug of enalaprilat Lysine derivatives, belonging to ...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61P9/00A61P9/12A61K31/549A61K31/4422
CPCA61K31/4422A61K31/549A61K38/05A61K2300/00
Inventor 朱正标陶元明张汉华李苗苗范小雪
Owner 江苏黄河药业股份有限公司
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