An experimental device for making animal models of chronic epilepsy
A technology for epilepsy animals and experimental devices, applied in the field of animal testing, can solve problems such as low success rate, and achieve the effects of complete functions, high space utilization, and reasonable design
Active Publication Date: 2018-09-07
GUIZHOU PROVINCIAL PEOPLES HOSPITAL
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Problems solved by technology
[0008] In order to study the principle and treatment plan of epilepsy, the patent CN201120062009.7 proposes a chest compression instrument for compressing the chest of animals, but this device is relatively simple, and there are many causes of epilepsy. Simply perform chest compression to achieve the effect of producing animal epilepsy The success rate of the experiment is low, so a device that can provide multiple epilepsy triggers and monitor the animal's physiological parameters in real time is needed to improve the success rate of the experiment
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[0028] In order to facilitate the understanding of the embodiments of the present invention, specific embodiments are taken as examples below for further explanation, and the embodiments do not constitute limitations on the embodiments of the present invention.
[0029] Such as figure 1 As shown, an experimental device for producing an animal model of chronic epilepsy, wherein the epilepsy-inducing modes include five modes of external chest compression stimulation, environmental hypoxia stimulation, temperature stimulation, light stimulation and vertigo stimulation, and the above five stimulations can be independently Implementation or any combination of several types, the combined epilepsy inducing device has complete stimulation methods, which can greatly improve the success rate of the experiment. It mainly includes a test box 1, a movable pallet 2, a control room 3, a power distribution room 4 and a lifting and pressing device 5. The test box 1 is divided into an upper roo...
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The invention discloses an experimental device for manufacturing a chronic epilepsy animal model. The experimental device mainly comprises an experimental box, a movable support board, a control room, a power distribution room and a rising and falling pressing device, wherein the movable support board separates the experimental box into an upper chamber and a lower chamber, the movable support board is provided with a limiting fixing device and a brain wave monitoring device, the right side of the movable support board is connected with a turning reducer, a coupler and a motor in sequence through a rotation shaft, the control room is positioned on the right side of the experimental box, the power distribution room is positioned below the control room, the rising and falling pressing device is positioned behind the experimental box, an LED lamp plate is arranged on a bottom board of the lower chamber of the experimental box, an audio-frequency generator is arranged on the right side wall, an air storage tank is connected to the rear side wall, and a refrigerator is connected to the left side wall. The experimental device is reasonable in design and complete in function, the death rate of experimental rats is greatly reduced, and the experimental success rate is improved.
Description
technical field [0001] The invention belongs to the technical field of animal experiments, and in particular relates to an experimental device for manufacturing chronic epilepsy animal models. Background technique [0002] Epilepsy is one of the most common nervous system diseases. Currently, epilepsy is defined as temporary central nervous system dysfunction caused by recurrent (generally more than three) abnormal discharge of neurons, and its neurosurgery has organic damage. The prevalence of epilepsy is 0.5--0.7%. There are about 35 million cases in the world, and about 6.5 million patients in my country are suffering from it. Recurrent epilepsy can cause the selective death of neurons in important structures such as the hippocampus, resulting in impairments in memory, cognition, and emotion. [0003] In recent years, although some progress has been made in the operation and drug treatment of epilepsy, about 30% of epilepsy patients are still difficult to completely cont...
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IPC IPC(8): A61D7/00A61D1/00
CPCA61D1/00A61D7/00
Inventor 李世容胡晓刘蕊李玫瞿浩
Owner GUIZHOU PROVINCIAL PEOPLES HOSPITAL