Method for calibrating a device for measuring the concentration of creatinine
一种测量设备、肌酸酐的技术，应用在测量装置、通过电磁手段进行材料分析、生物测试等方向，能够解决最终用户不经济、不精确、体积不精确等问题
Active Publication Date: 2017-08-29
RADIOMETER AS
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Problems solved by technology
[0012] In both cases, setting a 14-day time limit for achieving the accuracy of the calibration solution is disadvantageous because frequent replacement is required, which is neither economical nor convenient for the end user
Furthermore, this short pot life can be shortened even further, as the end user may have to wait several days for the solution to be shipped from the manufacturer
Alternatively, the end user may have to prepare the calibration solution at the point of use (e.g., hospital), which creates additional work for the end user and can cause inaccuracies or inhomogeneities in, for example, weighing Cr and Crn powders and measuring volumes of solvents. risk of imprecision
to be able to use t 时限 There is an unmet need for >14 day calibration solution methods
Method used
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[0037] will now refer to figure 1 , which is a schematic diagram of a three-electrode amperometric measurement system 101 . An amperometric measurement system may have at least two electrodes: a working electrode (WE) 110 and a combined counter and reference electrode (CE / RE). For the three-electrode amperometric system 101 , the function of the CE / RE electrodes is split into two separate electrodes: a reference electrode (RE) 111 and a counter electrode (CE) 112 . The example amperometric measurement system 101 also includes an ammeter 120 , a voltmeter 121 and a voltage source 122 and an electrolyte solution 140 .
[0038]WE 110 is the positively charged electrode where the oxidation reaction takes place. RE 111 is typically made of Ag / AgCl and is able to maintain a steady potential (especially if no current flows through it), so CE 112 is required to allow current from WE 110 to flow back to electrolyte solution 140 . Electrolyte solution 140 / sample provides a current pa...
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A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and / or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and / or Cm in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and / or Cm.
Description
technical field [0001] The present invention relates to methods for calibrating creatinine measuring devices, and calibration solutions for these methods. Background technique [0002] Techniques for measuring concentrations of creatinine (Crn) and creatine (Cr) are useful in medicine, for example in monitoring kidney disease. The concentrations of Cr (cCr) and Crn (cCrn) in aqueous solutions can be determined by amperometry. cCrn was measured using two sensors: a Crea A sensor that detects Cr; and a Crea B sensor that detects both Cr and Crn. cCrn is based on the difference between Crea A and Crea B sensor measurements. [0003] In order to determine cCrn in unknown samples with sufficient precision, the Crea A and Crea B sensors must be calibrated periodically in order to determine their actual sensitivity. These sensors can be calibrated using two aqueous calibration solutions of known cCrn and cCr. However, one problem with such calibration solutions is that cCr and ...
Claims
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IPC IPC(8): G01N27/327
CPCG01N27/3274G01N2333/986G01N2333/90683C12Q1/005G01N33/70
Inventor T.克亚尔
Owner RADIOMETER AS