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Drying device

A drying device and drying technology, applied in the direction of drying gas arrangement, drying solid materials, drying, etc., can solve the problems of cumbersome process operation, high device requirements, and inability to fully meet industrial production, and achieve good dissolution rate and stability Good results

Inactive Publication Date: 2017-09-19
JIANGSU HENGRUI MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology still has high requirements on the device, and the whole process operation is cumbersome, which cannot fully meet the needs of industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Refer to the method reported in WO2012146099 and other literatures to prepare crude caspofungin acetate. Dissolve the crude product in ethanol solvent at a temperature of 15-20℃, maintain the temperature and filter the aforementioned solution into a fine drying bag, and gradually add ethyl acetate , Stir to crystallize, and filter to obtain a solid. Then carry out drying treatment as follows:

[0045] 1) Turn on the temperature control device, and the cooling liquid enters the gap between the inner and outer walls of the box (31) through the liquid inlet (315) provided on the box (31), so as to control the temperature in the drying device at -30~ -20℃ requirement;

[0046] 2) Open the box cover (32), place the sample of caspofungin acetate to be dried in the box body (31), close the box cover (32), close the pressure reducing valve, and use the vacuum device to dry the sample from the air outlet (5) Pump the vacuum carrier into the device and close the air outlet (5);

[00...

Embodiment 2

[0069] Example 2: Preparation of caspofungin with reference to literature methods

[0070] Caspofungin was prepared with reference to the method reported in WO2012146099, and the purity of caspofungin acetate to be dried was about 99.10%, and then passed through WO94 / 21677, WO2010008496, WO2009151341, J.Org.Chem., 2007,72,2335-2343, respectively. And the method of WO2010108637 to dry the obtained caspofungin acetate.

[0071] Sample solubility test

[0072] Take the aforementioned appropriate amount of caspofungin to be easily soluble in 0.1 mol / L hydrochloric acid and water, and dissolve in ethanol.

[0073] Inspection method: Method for determination of solubility in the second part of the Chinese Pharmacopoeia 2010

[0074] Operation method: Weigh the test sample, stir and dissolve it in a certain amount of solvent at 25℃±2℃. If there are no visible solute particles, it is regarded as completely dissolved.

[0075] According to relevant regulations of Chinese Pharmacopoeia: Solubilit...

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PUM

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Abstract

The invention provides a drying device, comprising: an air inlet (1), a ventilation part (2), a drying box (3) and an air outlet (5), the ventilation part (2) is a hollow structure, and the ventilation part ( 2) The surface is provided with a plurality of ventilation holes (24). The drying has the advantages of low manufacturing cost, simple and practical, easy to clean and suitable for drying substances with poor stability.

Description

Technical field [0001] The invention relates to a drying device. Background technique [0002] For high value-added foods and medicines, in order not to damage their active ingredients and obtain high-quality, low-residual solvents, and stable performance products, freeze-drying is usually used. As described in CN201335597Y, this technology needs to dissolve the sample to be processed first, prepare it into a solution, and then contact a cold medium (such as liquid nitrogen) to produce a frozen solid, which is then dehydrated into a powder under high vacuum conditions . First of all, this technology needs to be carried out at a very low temperature, and the requirements for the device are relatively high, and a high-value device needs to be invested; secondly, it is necessary to strictly control the freeze-drying process parameters to control the entire freeze-drying process. In addition, the yield of the freeze-drying process is affected by the freeze-drying device and the fre...

Claims

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Application Information

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IPC IPC(8): F26B5/06F26B21/00A61K38/12
CPCF26B5/06A61K38/12F26B21/00
Inventor 王俊琰
Owner JIANGSU HENGRUI MEDICINE CO LTD