Nanomaterial composition, synthesis, and assembly
A composition and nanotube technology, which can be used in drug combination, drug delivery, organic active ingredients, etc., and can solve problems such as side effects and obstacles
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[0478] Preparation and application of nanometer material of the present invention
[0479] In particular embodiments, compounds of the invention may be used as nanocarriers for delivery of diagnostic or medical agents into cells. These compounds can be assembled into nanostructures, including nanotubes and / or nanosheets, which mimic or structurally mimic nucleic acid base pairs.
[0480] Provided herein is a method of making a nanotube-formulation complex. The method comprises combining a solution containing a compound of the invention with one or more agents (e.g., diagnostic or medical agents, e.g. siRNA, molecular beacons), wherein the compound self-assembles into nanotubes, and one or more agents Incorporation into nanotubes forms a nanotube-agent (population) complex whereby the agent (population) is delivered.
[0481] Alternatively, the method comprises combining a solution containing a compound of formula (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) with one o...
example 1
[0577] Example 1: Compounds of the following formula:
[0578]
[0579] Wherein n is an integer from 1 to 6.
[0580] and R 1 For having an α or β-amino covalent bond (CH 2 ) n α or β-amino acids (in this case, amino acids refer to both D- and L-amino acids); or have terminal α or β-amino covalently bonded (CH 2 ) n carbon poly-alpha or beta-peptide. n is an integer starting from 0. The structures shown below are examples of some α or β-amino acids:
[0581]
[0582] R 1 The structure should also include the following structure:
[0583] and
[0584] In the above structure, j is an integer starting from 0, k is an integer starting from 0, m is an integer starting from 0, and p is an integer starting from 0; R x is aliphatic or hydrogen; R y is hydrogen or the following structure:
[0585] Among them, q, s and t are integers starting from 0.
[0586] and R 2 It is hydrogen, methyl, amino or the following structure:
[0587] where R z is aliphatic. ...
example 2
[0588] Example 2: Compounds of the following formula:
[0589]
[0590] Wherein n is an integer from 1 to 6.
[0591] and R 3 For having α or β-amino covalently bonded two (CH 2 ) n α or β-amino acids at the carbons of the linker (in this case amino acids refer to both D- and L-amino acids); or two (CH 2 ) n Poly-α or β-peptides of the carbons of the linker. The structures shown below are examples of some α or β-amino acids:
[0592]
[0593] R 3 The structure should also include the following structure:
[0594] and
[0595] In the above structure, k is an integer starting from 0, m is an integer starting from 0, and p is an integer starting from 0; R x is aliphatic or hydrogen; R y is hydrogen or the following structure:
[0596] Among them, q, s and t are integers starting from 0.
[0597] and R 4 It is hydrogen, methyl, amino or the following structure:
[0598] where R z is aliphatic.
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