Composition containing catalase and application thereof

Abstract

The invention discloses a composition containing catalase and an application thereof. The composition comprises radionuclide, soluble alginate and catalase labeled on a biological macromolecule. The composition can be injected into a tumor by means of interventional therapy. When alginate ions in the composition enter the tumor to encounter calcium ions, a gel is formed, so that radionuclide and catalase are uniformly defined in the tumor. According to the composition containing catalase disclosed by the invention, the anoxic state of the tumor cell is improved by decomposing dissolved oxygen generated by hydrogen peroxide in the tumor by means of catalase, and meanwhile, the tumor cells after anoxic improvement are killed by means of radioactive rays, so that the composition has a good tumor treating application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for preparing antitumor agents and its application. Background technique [0002] Radionuclides have different enrichment effects in different organs and tissues. For example, thyroid cells have a special affinity for iodide. After a certain amount of iodine-131 is taken orally, it can be absorbed by the thyroid gland in large quantities. Iodine-131 decays into xenon- At 131, it can emit β-rays (99%) and γ-rays (1%). The effective range of the former is 3.63mm, and the average range is 0.48mm. It can selectively destroy the thyroid acinar epithelium without affecting adjacent tissues. But the enrichment effect also limits the application of radionuclides in other tissues. In the prior art, minimally invasive implantation therapy by radiating particles is currently one of the more ideal methods. Radioactive materials are placed in microcarriers, and radioactive see...

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Problems solved by technology

This method will permanently leave the carrier particles in the patient's body, which will have a long-term impact on the patient's body. This implantation method also has problems such as uneven distribution and poor coverage, and it is difficult to achieve the desired effect.

[0003] On the other hand, due to the disordered growth of tumors and insufficient angiogenesis, most human solid tumors have oxygen deficiency problems. The ability of tumor cells in a hypoxic state to resist ionizing radiation is several times higher than that of tumor cells with normal oxygen content. The reason is that the damage of oxygen free radicals to DNA is reduced, so radiation has limited lethality to hypoxic tumor cells, resulting in the ineffective therapeutic effect of existing radiation particles

One type of solution in the prior art is to increase the dissolved oxygen concentration in the body by means of a hyperbaric oxygen chamber; another type of method usually uses hypoxic cell sensitizers to reduce the dose of radiation or enhance the effect of radiotherapy, but radiosensitization Drugs are usually highly toxic and will cause adverse effects on the patient's body

For example, a class of nitroaromatic compounds with electrophilic active structures can participate in the bioreductive metabolism of hypoxic cells, weaken the simulation effect of nitro on oxygen, and can fix DNA damage under hypoxic conditions so that DNA damage cannot be repaired. Due to its large side effects, it is greatly restricted in clinical use

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