A composition comprising catalase and its application

Abstract

The invention discloses a composition containing catalase and its application, comprising radionuclides marked on biological macromolecules, soluble alginate and catalase. The composition can be injected into the tumor through interventional therapy, and when the alginate ion in the composition enters the tumor and encounters calcium ions, it will form a gel, thereby uniformly confining the radionuclide and catalase in the tumor . The composition containing catalase disclosed in the present invention uses catalase to decompose intratumoral hydrogen peroxide to produce dissolved oxygen to improve the hypoxic state of tumor cells, and at the same time, uses radioactive rays to kill the tumor cells after hypoxia improvement, It has a good application prospect in tumor therapy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for preparing antitumor agents and its use. Background technique [0002] Radionuclides have different enrichment effects in different organs and tissues. For example, thyroid cells have a special affinity for iodide. After a certain amount of iodine-131 is taken orally, it can be absorbed by the thyroid gland in large quantities. Iodine-131 decays into xenon- At 131, it can emit β-rays (99%) and γ-rays (1%). The effective range of the former is 3.63mm, and the average range is 0.48mm. It can selectively destroy the thyroid acinar epithelium without affecting adjacent tissues. But the enrichment effect also limits the application of radionuclides in other tissues. In the prior art, minimally invasive implantation therapy by radiating particles is currently one of the more ideal methods. Radioactive materials are placed in microcarriers, and radioactive seeds are i...

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Problems solved by technology

This method will permanently leave the carrier particles in the patient's body, which will have a long-term impact on the patient's body. This implantation method also has problems such as uneven distribution and poor coverage, and it is difficult to achieve the desired effect.

[0003] On the other hand, due to the disordered growth of tumors and insufficient angiogenesis, most human solid tumors have oxygen deficiency problems. The ability of tumor cells in a hypoxic state to resist ionizing radiation is several times higher than that of tumor cells with normal oxygen content. The reason is that the damage of oxygen free radicals to DNA is reduced, so radiation has limited lethality to hypoxic tumor cells, resulting in the ineffective therapeutic effect of existing radiation particles

One type of solution in the prior art is to increase the dissolved oxygen concentration in the body by means of a hyperbaric oxygen chamber; another type of method usually uses hypoxic cell sensitizers to reduce the dose of radiation or enhance the effect of radiotherapy, but radiosensitization Drugs are usually highly toxic and will cause adverse effects on the patient's body

For example, a class of nitroaromatic compounds with electrophilic active structures can participate in the bioreductive metabolism of hypoxic cells, weaken the simulation effect of nitro on oxygen, and can fix DNA damage under hypoxic conditions so that DNA damage cannot be repaired. Due to its large side effects, it is greatly restricted in clinical use

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