Gel material for efficient treatment of tumors and preparation method thereof

A gel material and high-efficiency technology, applied in the field of medical nano-biomaterials, can solve the problems of body function of patients with toxic and side effects, failure to effectively suppress cancer mortality, physical and mental trauma of patients, etc., and achieve the effect of high-efficiency responsive enzyme-catalyzed reaction

Active Publication Date: 2017-10-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current main treatment methods for tumors are traumatic surgery and chemotherapy. The current effects often not only fail to effectively suppress cancer mortality, but the toxic and side effects of long-term treatment will also cause a sharp decline in the patient's body function, resulting in iatrogenic, drug-sourced Diseases proliferate, and treatment itself creates new physical and psychological trauma and even disability for patients

Method used

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  • Gel material for efficient treatment of tumors and preparation method thereof
  • Gel material for efficient treatment of tumors and preparation method thereof
  • Gel material for efficient treatment of tumors and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A functional organic-inorganic hybrid nanogel material system carrying superoxide dismutase (SOD)-chloroperoxidase (CPO), specifically according to the following steps:

[0059] (1) Prepare 100 mg of Fe3O4 nano-cores (MNPs) by traditional pyrolysis method, disperse in a mixture of 80 mL of ethanol and 80 mL of deionized water, disperse ultrasonically for 30 min, add 6 mL of APTES, and react for 24 h under heating and stirring at 70 °C , and pass into N2. After the reaction was completed, they were washed several times with ethanol and deionized water respectively, and the obtained particles were surface aminated ferric oxide, ie MNPs-APTES. Then disperse the obtained MNPs-APTES in 100mL of DMF, add 10% succinic anhydride, stir and react for 18h, wash with ethanol and water to obtain the surface carboxylated ferric oxide MNPs-COOH, disperse the MNPs-COOH Reserve in 20mL deionized water to finally realize the carboxyl functionalization of the nano-core.

[0060] (2) Aft...

Embodiment 2

[0070] (1) Prepare 100 mg of Fe3O4 nano-cores (MNPs) by traditional pyrolysis method, disperse in a mixture of 70 mL of ethanol and 70 mL of deionized water, disperse ultrasonically for 20 min, add 4 mL of APTES, and react for 20 h under heating and stirring at 60 °C , and pass into N2. After the reaction was completed, they were washed several times with ethanol and deionized water respectively, and the obtained particles were surface aminated ferric oxide, ie MNPs-APTES. Then disperse the obtained MNPs-APTES in 100mL of DMF, add 8% succinic anhydride, stir the reaction for 16h, wash with ethanol and water to obtain the surface carboxylated ferric oxide MNPs-COOH, disperse the MNPs-COOH Reserve in 20mL deionized water to finally realize the carboxyl functionalization of the nano-core.

[0071] (2) After the above modification, the surface has a large number of carboxyl groups, which can be activated by EDC / NHS first, and then acid phosphatase (AP) can be grafted on the surfa...

Embodiment 3

[0075] (1) Prepare 100 mg of Fe3O4 nano-cores (MNPs) by traditional pyrolysis method, disperse in a mixture of 90 mL of ethanol and 90 mL of deionized water, disperse ultrasonically for 30 min, add 8 mL of APTES, and react for 30 h under heating and stirring at 80 °C , and pass into N2. After the reaction was completed, they were washed several times with ethanol and deionized water respectively, and the obtained particles were surface aminated ferric oxide, ie MNPs-APTES. Then disperse the obtained MNPs-APTES in 100mL of DMF, add 12% succinic anhydride, stir and react for 18h, wash with ethanol and water to obtain surface carboxylated ferric oxide MNPs-COOH, disperse MNPs-COOH Reserve in 20mL deionized water to finally realize the carboxyl functionalization of the nano-core.

[0076] (2) After the above modification, the surface has a large number of carboxyl groups, which can be activated by EDC / NHS first, and then acid phosphatase (AP) can be grafted on the surface. Take ...

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Abstract

The invention relates to a gel material for efficient treatment of tumors and a preparation method thereof. The gel material is composed of a micro organic-inorganic hybrid nano-gel carrier and a bio-enzyme component loaded on the micro organic-inorganic hybrid nano-gel carrier. The micro organic-inorganic hybrid nano-gel carrier comprises an inorganic nanoparticle core and an organic gel layer compounded on the surface of the inorganic nanoparticle core, wherein the organic gel layer is formed by deposition and self-assembly of a gelling factor on the surface of the inorganic nanoparticle core, and the gelling factor is Fmoc- or Nap- functionalized small molecular polypeptide with an aromatic substituent group. Compared with the prior art, the micro organic-inorganic hybrid nano-gel carrier adopted by the invention provides natural protection for loading and immobilization of bio-enzyme, glucose responsive and reactive oxygen species responsive efficient and tandem enzyme-catalyzed reaction is carried out at a tumor site, tumor lesion site or other lesion sites to generate singlet oxygen, thus realizing efficient and safe treatment.

Description

technical field [0001] The invention relates to the technical field of medical nano-biological materials, in particular to a gel material for efficient treatment of tumors and a preparation method thereof. Background technique [0002] In recent years, the incidence of malignant tumors in my country has been increasing year by year, seriously endangering human health. The current main treatment methods for tumors are traumatic surgery and chemotherapy. The current effects often not only fail to effectively suppress cancer mortality, but the toxic and side effects of long-term treatment will also cause a sharp decline in the patient's body function, resulting in iatrogenic, drug-sourced Diseases proliferate, and the treatment itself creates new physical and psychological trauma and even disability for patients. How to achieve a safer and more effective tumor treatment has become a major social issue, and it is also a difficult problem that researchers in materials, chemistry...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/18A61K47/02A61K47/04A61K47/42A61K41/00A61K49/22A61K49/14A61K49/18A61K49/00
CPCA61K9/06A61K41/0057A61K47/02A61K47/183A61K47/42A61K49/0002A61K49/14A61K49/1803A61K49/226
Inventor 王启刚王霞吴青位青聪
Owner TONGJI UNIV
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