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Method for determining quantitative indexes of sensibility and drug tolerance, for antibiotics, of helicobacter pylori

A technology for determining Helicobacter pylori and indicators, applied in instruments, calculations, electrical digital data processing, etc., can solve the problems of unguaranteed treatment success rate, no effective antibiotic treatment and infection prevention

Active Publication Date: 2017-10-17
SHANDONG UNIV
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  • Abstract
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Problems solved by technology

At the same time, the emergence of bacterial resistance puts the achievements of modern medicine in jeopardy. Without effective antibiotic treatment and prevention of infection, the success rate of organ transplantation, cancer chemotherapy and major surgery cannot be guaranteed.

Method used

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  • Method for determining quantitative indexes of sensibility and drug tolerance, for antibiotics, of helicobacter pylori
  • Method for determining quantitative indexes of sensibility and drug tolerance, for antibiotics, of helicobacter pylori
  • Method for determining quantitative indexes of sensibility and drug tolerance, for antibiotics, of helicobacter pylori

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Embodiment Construction

[0033] It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0034] It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0035] Taking Helicobacter pylori and clarithromycin as an example, building an equivalent circuit model refers ...

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Abstract

The invention discloses a method for determining quantitative indexes of sensibility and drug tolerance, for antibiotics, of helicobacter pylori. According to the method, growth / killing curves, for antibiotics, of the helicobacter pylori are utilized to establish a fractional order equivalent circuit model for reaction between the helicobacter pylori and the antibiotics; and correlation between parameters of the model and sensibility and drug tolerance mechanisms in the bacteria is established, so as to quantitatively describe a sensibility and drug tolerance mechanism, for the antibiotics, of the helicobacter pylori and provide quantitative new indexes for clinical examinations.

Description

technical field [0001] The invention belongs to the field of quantitative index calculation, and in particular relates to a quantitative index determination method for antibiotic sensitivity and drug resistance of Helicobacter pylori. Background technique [0002] In 1994, the World Health Organization / International Agency for Research on Cancer (WHO / IARC) classified Helicobacter pylori as a class I carcinogen. Epidemiological studies have shown that the natural infection rate of Helicobacter pylori in the world exceeds 50%, and there is almost no pathogenic microorganism in the world that infects half of the global population. my country is a high-incidence area of ​​gastric cancer, which is closely related to the high infection rate of Helicobacter pylori (70%). Therefore, the key to controlling the incidence of gastric cancer is the treatment of Helicobacter pylori. [0003] The current primary prevention of gastric cancer aimed at eradicating Helicobacter pylori has its...

Claims

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Application Information

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IPC IPC(8): G06F19/00
CPCG16C20/50
Inventor 李岩王文超孙允东耿熙炆
Owner SHANDONG UNIV
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