Design method for heart failure model of human ventricular muscle tissue

A design method and heart failure technology, applied in computing, special data processing applications, instruments, etc., can solve the problems of lack of human heart failure model establishment, failure to consider calculation stability and efficiency, etc., to deepen understanding and ensure simulation results. Effect

Active Publication Date: 2017-10-20
DALIAN UNIV OF TECH
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Problems solved by technology

[0007] Through the analysis of the current research status, it is found that most of them focus on the animal heart as the research object, lack of the establishment of human heart failure model, and do not consider the stability and efficiency of calculation

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  • Design method for heart failure model of human ventricular muscle tissue
  • Design method for heart failure model of human ventricular muscle tissue
  • Design method for heart failure model of human ventricular muscle tissue

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Embodiment Construction

[0056] In order to make the object of the present invention, technical scheme and advantage clearer, below in conjunction with two-dimensional ventricular muscle tissue (assuming that the tissue area is 30cm * 30cm, the space step is Δx=Δy=0.05cm, then the simulated myocardial tissue sheet contains 601 ×601 cells) generation and development process of the helical wave, at the same time to obtain the pseudo electrocardiogram P-ECG under heart failure, give a specific embodiment and refer to the accompanying drawings, and describe the present invention in detail. This embodiment is carried out on the premise of the technical solution of the present invention, and provides detailed implementation and specific operation process, but the protection scope of the present invention is not limited to the following embodiments.

[0057] The first step is to determine the cell stimulation protocol

[0058] Apply 10 consecutive stimuli to a single cell of human ventricular muscle tissue, ...

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Abstract

The invention discloses a design method for a heart failure model of a human ventricular muscle tissue, and belongs to the technical field of virtual human hearts. Heart failure is taken as a research object, and myocardial electrophysiological and mechanics characteristics and a spiral wave dynamics mechanism under heart excitation-contraction coupling are discussed to discover a relationship of interaction between the heart failure and arrhythmia. A TP06 model simulates a single ventricular muscle cell of a human body, then the TP06 model is coupled to an NHS08 model, and an ECC model is built; based on an improved TP06 model and existing data, a human ventricular heart failure muscle cell model is built, and the electrophysiological and mechanics characteristics of human ventricular muscle cells, an action potential duration restitution curve and an early afterdepolarization restitution curve under normal and heart failure conditions are compared; finally by adding coupling among the cells, a two-dimensional single-layer myocardial tissue action potential conduction model is successfully built, and spiral waves are induced by adopting a ''wave shearing method''; and then, dynamics characteristics of the spiral waves under the normal and heart failure conditions are compared.

Description

technical field [0001] The invention belongs to the technical field of a virtual human heart, in particular to a design method of a heart failure model of human ventricular muscle tissue. Background technique [0002] According to epidemiological data in 2010, the number of chronic heart failure (CHF, referred to as heart failure) patients in the world has reached 22.5 million, and it is still increasing at a rate of 2 million per year. It was 0.9% and showed an increasing trend year by year. [0003] When the heart fails, its physiology and structure undergo tremendous changes, and the changing factors affect each other. Therefore, traditionally, it is useful to analyze the impact of heart failure on the overall electrophysiological and mechanical function characteristics of the heart from the clinical and anatomical perspectives. limited. With the development of computer technology, more and more researchers have begun to use computer virtual heart models to conduct quan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 张方方刘海龙周维帅张昕
Owner DALIAN UNIV OF TECH
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