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Retroperitoneal fibrosis and infection resistant peritoneal dialysis solution and preparation method thereof

A technology of peritoneal dialysis fluid and fibrosis, which is applied in the field of medicine, can solve undisclosed problems, achieve anti-infection synergy, good stability, and improve the effect of ultrafiltration

Active Publication Date: 2017-10-24
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It has been revealed that curcumadione has the functions of regulating immunity, anti-tumor, anti-pathogen, and analgesia, but there is no related research on the application of curcumadione in peritoneal dialysate.

Method used

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  • Retroperitoneal fibrosis and infection resistant peritoneal dialysis solution and preparation method thereof
  • Retroperitoneal fibrosis and infection resistant peritoneal dialysis solution and preparation method thereof
  • Retroperitoneal fibrosis and infection resistant peritoneal dialysis solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] The preparation method of Comparative Example 0-3 is carried out according to the above-mentioned method according to the raw materials of Comparative Example 0-3.

[0041] Experiment 1 Evaluation against fibrosis

[0042] 1. Purpose of the experiment

[0043] By comparing and analyzing indicators: rat peritoneal thickness and rat ascites and blood TGF-β1 concentration, to evaluate the anti-peritoneal fibrosis effect of the peritoneal dialysis solution in Examples 1-4 of the present invention.

[0044] 2. Experimental method

[0045] (1) Determination of rat peritoneal thickness

[0046] The peritoneal dialysis solution described in Comparative Example 0 and Examples 1-4 was put into a three-layer co-extrusion film bag for infusion, and sterilized by moist heat at a sterilization temperature of 115° C. and a sterilization time of 30 minutes.

[0047] 90 male SD rats were divided into 9 groups according to random number table, i.e. group A-group I, 10 in each group, w...

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Abstract

The invention provides a retroperitoneal fibrosis and infection resistant peritoneal dialysis solution. The peritoneal dialysis solution is prepared from an electrolyte, a permeating agent and curdione, wherein the electrolyte is prepared from one or more of sodium chloride, calcium chloride and magnesium chloride; the permeating agent is prepared from one or more of glucose, dextran and fructose; the peritoneal dialysis solution also can be prepared from buffer base, wherein the buffer base is lactate and / or bicarbonate, the content of the curdione is 0.03 to 2 percent by weight / volume, and the curdione has a key effect on resisting retroperitoneal fibrosis. By adopting a reasonable formula, the peritoneal dialysis solution disclosed by the invention can have better retroperitoneal fibrosis and infection resistant effects, thus improving the ultra-filtration efficiency.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a peritoneal dialysate for resisting peritoneal fibrosis and infection and a preparation method thereof. Background technique [0002] As a treatment method for patients with end stage renal disease (ESRD), peritoneal dialysis has been widely used in recent years due to its special advantages such as home treatment, easy operation, reduction of blood-borne disease transmission, and protection of residual renal function. Applications. The principle is that the peritoneum is used as a semipermeable membrane, and the fresh dialysate is constantly replaced to achieve the purpose of removing excess water and toxins in the body. Compared with the dialysis membrane of hemodialysis, the peritoneum has a larger pore size, so it can remove large, medium and small molecule toxins. [0003] However, in order to maintain the osmotic gradient, currently commercially available peritoneal d...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P13/12A61P7/08A61P31/00A61P29/00A61K31/7004A61K31/122A61K31/19
CPCA61K31/122A61K31/19A61K31/7004A61K33/14A61K2300/00
Inventor 李继仁冯新光
Owner HUAREN PHARMACEUTICAL CO LTD
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