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A method to restore the rumen microflora of dairy cows after antibiotic use

A technology of antibiotics and rumen flora, applied in the field of microbiology, can solve the problems of reducing the production performance and health level of dairy cows, disordering the rumen microbial community of dairy cows, affecting animal metabolism and health, etc., to avoid the loss of rumen flora, reduce centrifugation, The effect of guaranteeing activity

Active Publication Date: 2020-03-20
CHINA AGRI UNIV
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Problems solved by technology

Studies in both humans and mice have shown that antibiotic-induced disturbances in the gut microbiome do not recover after months or years, resulting in long-term effects on the metabolism and health of the animals
The nutrient digestion of dairy cows is highly dependent on a healthy rumen microbial community, and the use of antibiotics has also led to long-term disturbances in the rumen microbial community of dairy cows, reducing the performance and health of dairy cows
At present, there is no literature report on promoting the recovery of rumen microflora in dairy cows after antibiotic use by rumen microflora transplantation technology

Method used

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  • A method to restore the rumen microflora of dairy cows after antibiotic use
  • A method to restore the rumen microflora of dairy cows after antibiotic use
  • A method to restore the rumen microflora of dairy cows after antibiotic use

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specific Embodiment approach

[0027] 1. Experimental animals and feeding conditions

[0028] 10 healthy dairy cows of similar age and body condition were selected as experimental animals, and 5 cows with rumen fistula were used as donor cows (already available in this experimental base). They were reared in groups in the farm, given the same ration, free access to food and water.

[0029] 2. Test processing and sample collection

[0030] (1) Construction of experimental animal models. Each test cow was intramuscularly injected with penicillin (8 million units) and streptomycin (5 million units) according to the therapeutic dose, once in the morning and evening, for 14 consecutive days.

[0031] (2) Acquisition of rumen flora fluid. The rumen flora liquid was obtained from the donor cow through a rumen fistula, filtered through two layers of medical gauze (pore size 0.15mm), and the filtrate was taken in a bucket with a cover, and 5ml of the rumen flora liquid was taken for pH measurement and microscopic ...

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Abstract

The invention relates to a method for restoring cow rumen microflora after antibiotic use. The method is characterized by comprising the following steps: (1) obtaining a rumen flora liquid containing healthy rumen microflora from healthy cows; (2) protecting the rumen flora through an anaerobic bacteria protective agent; and (3) transplanting the rumen flora liquid containing healthy rumen microflora to cows with antibiotic use. According to the method disclosed by the invention, the effect of rapidly restoring the cow rumen microflora can be achieved, so that harm of antibiotics to the cows and environment can be reduced, and the disease prevention and treatment aim can be achieved when necessary. Meanwhile, the method is simple and easy to operate and is suitable for actual application in the pasture.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a method for restoring the rumen microbial community of cows after using antibiotics. Background technique [0002] Antibiotics are commonly used medicines for the treatment or prevention of pathogenic bacterial infections in pastures. Because antibiotics can directly and quickly kill pathogenic bacteria, achieve the purpose of preventing and treating related diseases caused by pathogenic microorganisms, and industrially produced antibiotics are cheap, they are widely used as standing drugs for the treatment and prevention of dairy cow diseases. [0003] However, more and more evidence shows that whether the use of antibiotics is regulated or not, it threatens the health of humans and animals from two aspects: 1. The use of antibiotics leads to the disturbance of gastrointestinal microbial flora, which affects the immune regulation and anti-infection ability of animals. 2. Anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/741A61K47/26A61K47/20A61P1/00A61P31/04
CPCA61K35/741A61K47/20A61K47/26
Inventor 李胜利纪守坤严慧郭春燕蒋涛刘晶晶王雅晶曹志军
Owner CHINA AGRI UNIV
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