Film coating premix agent of probiotic preparation, as well as preparation method and application of film coating premix agent

A probiotic preparation and film coating technology, which is applied in the field of film coating premix for probiotic preparations and its preparation field, can solve the problems of reduced survival rate of probiotics, limited acid resistance, influence on microbial activity and the like, and achieve acid resistance. Strong, stable and easy to promote

Active Publication Date: 2017-11-03
BEIJING YINGMAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some obvious deficiencies in these technologies at present. For example, the impact of spray drying technology on microbial activity due to high temperature and drying dehydration during the processing of probiotic preparations is more obvious.
The embedding technology using sodium alginate as the main wall material has a limited acid resistance of the microcapsules made of sodium alginate, which greatly reduces the survival rate of probiotics after 2 hours in gastric juice

Method used

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  • Film coating premix agent of probiotic preparation, as well as preparation method and application of film coating premix agent
  • Film coating premix agent of probiotic preparation, as well as preparation method and application of film coating premix agent
  • Film coating premix agent of probiotic preparation, as well as preparation method and application of film coating premix agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] The film coating premix of probiotic preparations, by mass percentage, includes:

[0075] Methacrylic acid and ethyl acrylate copolymer 52%;

[0076] Talc powder 30%;

[0077] Plasticizer 6%;

[0078] Anti-sticking agent 11.95%;

[0079] Simethicone 0.05%.

[0080] In this embodiment, the ratio of methacrylic acid and ethyl acrylate copolymer is 1:1 in mass percent.

[0081] As described in this embodiment, the plasticizer is triethyl citrate.

[0082] As described in this embodiment, the anti-sticking agent is stearic acid.

[0083] Described in the present embodiment, a kind of manufacturing method of the film coating premix of probiotic preparation comprises the following steps:

[0084] Weigh methacrylic acid and ethyl acrylate copolymer, talcum powder and stearic acid according to the mass percentage and place them in a high-efficiency granulator, turn on the stirring equipment, and stir and mix for 10 to 15 minutes to make them uniform. Add triethyl citrate...

Embodiment 2

[0088] This embodiment is improved on the basis of Embodiment 1, and the content described in Embodiment 1 is also included in this embodiment, and will not be described in detail here.

[0089] The film coating premix of probiotic preparations, by mass percentage, includes:

[0090] Methacrylic acid and ethyl acrylate copolymer 56%;

[0091] Talc 28%;

[0092] Plasticizer 7%;

[0093] Anti-sticking agent 8.9%;

[0094] Simethicone 0.1%.

[0095] In this embodiment, the ratio of methacrylic acid and ethyl acrylate copolymer is 1:1 in mass percent.

[0096] As described in this embodiment, the plasticizer is triethyl citrate.

[0097] As described in this embodiment, the anti-sticking agent is stearic acid.

[0098] Described in the present embodiment, a kind of manufacturing method of the film coating premix of probiotic preparation comprises the following steps:

[0099] Weigh methacrylic acid and ethyl acrylate copolymer, talcum powder and stearic acid according to th...

Embodiment 3

[0103] This embodiment is improved on the basis of Embodiment 1, and the content described in Embodiment 1 is also included in this embodiment, and will not be described in detail here.

[0104] The film coating premix of probiotic preparations, by mass percentage, includes:

[0105] Methacrylic acid and ethyl acrylate copolymer 69.9%;

[0106] Talc powder 20%;

[0107] Plasticizer 8%;

[0108] Anti-sticking agent 2%;

[0109] Simethicone 0.1%.

[0110] In this embodiment, the ratio of methacrylic acid and ethyl acrylate copolymer is 1:1 in mass percent.

[0111] As described in this embodiment, the plasticizer is triethyl citrate.

[0112] As described in this embodiment, the anti-sticking agent is stearic acid.

[0113] Described in the present embodiment, a kind of manufacturing method of the film coating premix of probiotic preparation comprises the following steps:

[0114] Weigh methacrylic acid and ethyl acrylate copolymer, talcum powder and stearic acid accordin...

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Abstract

The invention relates to the technical field of a film coating premix agent of a probiotic preparation, in particular to a film coating premix agent of a probiotic preparation, as well as a preparation method and application of the film coating premix agent. The film coating premix agent of the probiotic preparation comprises the following components in percentage by mass: 50-70% of a methacrylic acid and ethyl acrylate copolymer, 20-30% of talcum powder, 6-8% of a plastifier, 2-12% of an antisticking agent and 0.05-0.1% of simethicone. The film coating premix agent as well as the preparation method and application thereof disclosed by the invention have the beneficial effects that an enteric type film coating technique is introduced into producing and processing of the probiotic preparation, so that probiotics are isolated from external environment, the influence of oxygen, moisture, carbon dioxide, light rays, temperature variation and the like in air is avoided, the stability of the probiotic preparation is guaranteed, and problems existing in the prior art are economically and effectively solved.

Description

technical field [0001] The invention relates to the technical field of film coating premix of probiotic preparations, in particular to the film coating premix of probiotic preparations and its preparation method and application. Background technique [0002] Probiotics are a type of active microorganisms that are beneficial to the host. They are a general term for active beneficial microorganisms that colonize the human body, the intestinal tract of animals, and the reproductive system, and can produce definite health effects, thereby improving the host's micro-ecological balance and exerting beneficial effects. Beneficial bacteria or fungi in humans and animals mainly include Clostridium butyricum, lactic acid bacteria, bifidobacteria, Lactobacillus acidophilus, actinomycetes, and yeasts. With the growing demand for high-quality animal products in the animal feed market, probiotic feed additives play an important role in providing balanced nutrition and improving digestibil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135
CPCA23L33/135
Inventor 胡崇茂
Owner BEIJING YINGMAO PHARMA
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