Uses of loganetin in preparation of antitumor medicines

An anti-tumor drug, the technology of logan aglycone, which is applied in the field of medicine, can solve the problems such as the anti-tumor biological activity or clinical application research of logan aglycone, which can reduce the economic burden, have a wide range of anti-tumor and relieve pain. Effect

Active Publication Date: 2017-11-21
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no research on the anti-tumor biological activity or clinical application of loganinin

Method used

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  • Uses of loganetin in preparation of antitumor medicines
  • Uses of loganetin in preparation of antitumor medicines
  • Uses of loganetin in preparation of antitumor medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Loganin Tablets

[0025]

[0026] Preparation process: mix loganin, microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are passed through a 20-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, pressed into tablets, each tablet is about 200mg, that is, .

Embodiment 2

[0027] Example 2 Loganinin Capsules

[0028] Loganin 10g

[0029] Microcrystalline Cellulose 300g

[0030] Micronized silica gel 12g

[0031] Preparation process: pulverize loganin, microcrystalline cellulose, and micropowder silica gel, pass through a 100-mesh sieve, mix well, and directly fill capsules.

Embodiment 3

[0032] Example 3 Loganinin Granules

[0033]

[0034] Preparation process: weigh the loganin, starch, dextrin, and sucrose powder in the prescribed amount and mix them evenly. Add an appropriate amount of 80% ethanol to the mixed powder, mix evenly, make a soft material, pass through a 18-mesh nylon sieve to make wet granules, dry at about 60°C, granulate with a 20-mesh sieve, and pack separately.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and relates to uses of loganetin in preparation of antitumor medicines. Tumors here include mammal gastric cancer, liver cancer, esophagus cancer, colorectal cancer, pancreatic cancer, lung cancer, head and neck cancer, leukemia, malignant lymphoma, prostatic cancer, breast cancer, glioma, carcinoma of bile duct, melanoma, kidney cancer, ovarian cancer, endometrial cancer and cervical cancer, and more specifically, human gastric cancer, human liver cancer, human esophagus cancer, human colorectal cancer, human pancreatic cancer, human lung cancer, human head and neck cancer, human leukemia, human malignant lymphoma, human prostatic cancer, human breast cancer, human glioma, human carcinoma of bile duct, human melanoma, human kidney cancer, human ovarian cancer, human endometrial cancer and human cervical cancer. In-vitro and in-vivo tests prove that the loganetin can inhibit the tumors well, shows good tumor growth inhibiting activity, and has great potential in development into antitumor medicines.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of loganin in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are diseases in which cell DNA suddenly mutates under certain conditions, resulting in uncontrolled cell division, resulting in continuous proliferation and metastasis, and finally leading to the death of the host. At present, the clinically available treatment methods for malignant tumors include surgery, radiotherapy, hyperthermia, chemotherapy, gene therapy, and immunotherapy. While the prior art has shown that it is possible to treat malignancies within a limited capacity using different techniques and treatments, these techniques and treatments all have some significant disadvantages. For example, chemotherapy as the main treatment method not only has limited anti-tumor effect, but also has relatively high toxicity and side effects, poor patient tolerance and high pri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P11/00A61P35/00
Inventor 张贵民姚景春李光艳王恩力
Owner SHANDONG NEWTIME PHARMA
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