Preparation method of nonionic vesicle with whitening effect

A non-ionic, non-ionic surface technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of poor product stability, single whitening mechanism, and low whitening efficiency, and achieve the goal of overcoming poor stability and improving Stability, the effect of simplifying the formulation process

Active Publication Date: 2017-11-24
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a preparation method of non-ionic vesicles capable of encapsulating multiple whitening active ingredients at the same time, which overcomes the single whitening mechanism, poor product stability, and whitening efficiency of whitening products in the prior art. Low, easy to cause skin irritation and other problems

Method used

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  • Preparation method of nonionic vesicle with whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of non-ionic vesicles with whitening effect:

[0036] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 3:1:3:2:1, wherein the traditional whitening agent is Glabridin and nicotinamide with a mass ratio of 1:1; the whitening active composition and dipropylene glycol are mixed in a mass ratio of 1:5 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;

[0037] B. Weigh glycerol oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 0.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is clear a...

Embodiment 2

[0041] A preparation method of non-ionic vesicles with whitening effect:

[0042] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 5:1:3:2:1, wherein the traditional whitening agent is Arbutin and 4-butylresorcinol with a mass ratio of 1:1; the whitening active composition and 1,3-butanediol are mixed in a mass ratio of 1:6 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;

[0043] B. Take glyceryl oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 1.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is clear and...

Embodiment 3

[0047] A preparation method of non-ionic vesicles with whitening effect:

[0048] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 6:1:3:2:1, wherein the traditional whitening agent is Ascorbyl glucoside and ascorbyl palmitate with a mass ratio of 1:1; the whitening active composition and glycerin are mixed in a mass ratio of 1:8 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;

[0049] B. Take glyceryl oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 2.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is cle...

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Abstract

The invention relates to a preparation method of a nonionic vesicle with a whitening effect. The preparation method is characterized by comprising following steps: step A, weighing a conventional whitening agent, hydroxyl phenoxyl propionic acid, phloretin, hydroxytyrosol, and a cyanotis arachoidea root extract according to a mass ratio of 3-10:1:3:2:1, and then mixing the mixture with polyol to obtain a whitening active composition solution; step B, weighing glyceryl oleate citrate, cetearyl glucoside, and polyglyceryl-3 methyl glucose distearate according to a mass ratio of 0.5-3:2:1, and adding magnolol to obtain a nonionic surfactant premix; step C, preparing a nonionic surfactant water solution; and step D, mixing the whitening active composition solution with the nonionic surfactant water solution according to a mass ratio of 1:2-4 to prepare the nonionic vesicle with a whitening effect. The vesicle can wrap multiple whitening active components and overcomes the problems such as single whitening mechanism, bad product stability, low whitening efficiency, easy triggering of skin irritation, and the like.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, in particular to a preparation method of non-ionic vesicles with whitening effect. technical background [0002] Whitening has always been paid close attention to by people, and whitening skin care products have also been highly praised and pursued by women. The skin color difference of the human body usually depends on factors such as the content and distribution of melanin in the epidermis, the collagen fiber structure of the dermis, and the thickness and water content of the stratum corneum. Among them, the type, quantity and distribution of melanin in keratinocytes determine the actual color of the skin. The synthesis of melanin is affected by many factors. For example, melanocyte-stimulating hormone (α-MSH) in the body can promote the proliferation of melanocytes and the expression of tyrosinase, and can also increase the enzyme-promoting factor Cu in the blood. 2+ concentration, the act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/9789A61K8/34A61K8/35A61K8/36A61K8/365A61K8/44A61K8/49A61K8/60A61K8/67A61Q19/02
CPCA61K8/14A61K8/345A61K8/35A61K8/36A61K8/365A61K8/44A61K8/498A61K8/602A61K8/675A61K8/676A61K8/97A61Q19/02
Inventor 黄洁芳蒋丽刚毕永贤王晗宁王丽娜李文倩金汉坤陈斌
Owner PROYA COSMETICS
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