A kind of pharmaceutical composition of Thiopeptidecycline

A technology of thiopeptidecycline and its composition, which is applied in the field of thiopeptidecycline pharmaceutical composition, can solve the problems of drug efficacy or safety that cannot be successfully developed into medicines, and achieve strong anti-(drug-resistant) bacteria activity, A wide variety of effects with significant application value
CN107469068BActive Publication Date: 2021-06-22NANJING BIOTICA PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING BIOTICA PHARMA
Publication Date
2021-06-22

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Abstract

Thiopeptidecycline is a thiopeptide antibiotic with strong anti-drug-resistant bacteria activity. It has broad clinical application prospects, but the disadvantage of poor solubility needs to be improved urgently. The invention discloses a pharmaceutical composition of thiopeptidecycline, which can significantly increase the solubility of thiopeptidecycline and increase the clinical application value of thiopeptidecycline. In addition, the thiopeptidecycline composition disclosed in the present invention can be used to prepare aqueous solution injections, non-aqueous solution injections, emulsion injections, suspension injections and sterile powders for injection.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition of thiopeptidecycline, which increases the solubility of poorly soluble thiopeptidecycline by preparing the pharmaceutical composition. Background technique

[0002] Poor water solubility is one of the important reasons why many active new chemical entities (NCEs) cannot be approved for marketing (JPharmacol Toxicol, 2009, 44:235). According to incomplete statistics, in recent years, the proportion of insoluble compounds in the new drug development product line has rapidly increased from about 40% ten years ago to 60%-70%, and this proportion may be even higher for injections. Therefore, how to effectively solve the solubility problem of compounds and improve the druggability of compounds has become one of the important challenges in the development of new drugs (Front Pharmacol, 2017, 8:261).

[0003] At present, the convention...

Claims

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