A bionic heart patch repair material and preparation method thereof

A technology for repairing materials and hearts, applied in the field of biomimetic materials, can solve problems such as restricting the development of myocardial patches, and achieve the effects of being beneficial to repair, good electrical conductivity, and accelerating vascularization

Inactive Publication Date: 2020-09-15
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current myocardial patches only meet the first condition, which limits the development of myocardial patches

Method used

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  • A bionic heart patch repair material and preparation method thereof
  • A bionic heart patch repair material and preparation method thereof
  • A bionic heart patch repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] (1) Preparation of functionalized hyaluronic acid

[0030] Weigh a certain amount of methacrylylated hyaluronic acid and dissolve it in distilled water to prepare a methacrylylated hyaluronic acid solution with a mass concentration of 5%. Weigh a certain amount of 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) were sequentially dissolved in distilled water to prepare an EDC / NHS solution, in which 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide (EDC) at a concentration of 6 mg / mL and N-hydroxysuccinimide (NHS) at a concentration of 1 mg / mL; methacrylylated hyaluronic acid solution and EDC Mix equal volumes of / NHS solution, stir at room temperature for 30-45min, then add an equal volume of 2-(2-pyridyldithio)ethylamine hydrochloride solution with a concentration of 0.3 mg / mL, and stir at room temperature for 1-2h , and finally add m methacryloyl hyaluronic acid according to the mass ratio:mREDV short peptide=1:0.025 Add REDV s...

Embodiment 1

[0038]According to the present invention, a kind of bionic heart patch repair material is prepared according to the above method, wherein: the REDV short peptide used in the preparation process has an amino acid sequence of Arg-Glu-Asp-Val, and the gold nanorods used have an aspect ratio of 2.5, the size (length × width) is 30 × 10nm; the computer-aided software used is AutoCAD, the 3D printer used is 3D systems company, the model is 3Dsystems ProX photocuring printer; the functionalized hyaluronic acid 30 1 part, 5 parts of methacrylated gelatin, 1 part of gold nanorod, 0.05 part of human adipose-derived mesenchymal stem cell, and 0.1 part of photoinitiator.

Embodiment 2

[0040] According to the present invention, a kind of bionic heart patch repair material is prepared according to the above method, wherein: the REDV short peptide used in the preparation process has an amino acid sequence of Arg-Glu-Asp-Val, and the gold nanorods used have an aspect ratio of 2.5, the size (length × width) is 30 × 10nm; the computer-aided software used is AutoCAD, the 3D printer used is 3D systems company, the model is 3Dsystems ProX photocuring printer; the functionalized hyaluronic acid 45 10 parts of methacrylated gelatin, 2.5 parts of gold nanorods, 0.075 parts of human adipose-derived mesenchymal stem cells, and 0.25 parts of photoinitiator.

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Abstract

The invention belongs to the technical field of bionic materials and discloses a bionic heart patch repairing material and a preparation method thereof. The bionic heart patch repairing material is composed of the following components in parts by weight: 30-60 parts of functional hyaluronic acid, 5-15 parts of methacrylic acid esterification gelatin, 1-5 parts of gold nanorods, 0.05-0.1 part of human adipose-derived mesenchymal stem cells and 0.1-0.5 part of a photoinitiator. The heart patch repairing material prepared by adopting the preparation method has highly bionics performance, excellent bioactivity and biocompatibility and no immunogenicity, and is moulded by virtue of a three-dimensional printing technology, can be modeled and moulded according to the actual situation of a patientand has the advantages of personalized treatment and precise treatment.

Description

technical field [0001] The invention belongs to the technical field of bionic materials, in particular to a bionic heart patch repair material and a preparation method thereof. Background technique [0002] Myocardial infarction is a disease that poses a greater threat to humans. When a heart vessel is infarcted, a certain range of myocardial cells will be lost and fibrous tissue will be formed to affect heart function. This damage to the heart is irreversible because adult cardiomyocytes cannot regenerate. The effective way to reverse this damage is to replenish the lost cardiomyocytes by directly injecting cardiomyocytes into the myocardial infarction area, but the survival rate of cardiomyocytes supplemented by this method is not high, and immune rejection and teratoma are prone to occur after injection . Tissue engineered myocardial patch is an effective treatment for cell repair after myocardial infarction. Tissue engineered scaffolds can mimic the structure and func...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/04A61L27/38A61L27/20A61L27/22
Inventor 韦加娜陈锦涛陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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