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Sulfur-containing alkaloid as well as preparation method and application thereof

A technology of alkaloids and curthiourea, which is applied in the field of sulfur-containing alkaloids and their preparation, can solve the problems of undeveloped material basis and effective component research, component differences, safety and effectiveness that need to be clarified urgently

Inactive Publication Date: 2018-01-09
YUNNAN MINZU UNIV
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Problems solved by technology

However, there are large differences in the composition of the same characteristic resource plant in different origins. The research on the pharmacological activity of maca introduced from China basically stays at the stage of activity evaluation of the extract, and no systematic research on the material basis and medicinal components has been carried out. , its safety and efficacy need to be elucidated

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  • Sulfur-containing alkaloid as well as preparation method and application thereof
  • Sulfur-containing alkaloid as well as preparation method and application thereof
  • Sulfur-containing alkaloid as well as preparation method and application thereof

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preparation example Construction

[0023] The preparation method of the sulfur-containing alkaloid of the present invention is based on the characteristic resource plant maca (Latin name: Lepidium meyenii Walp.) root as the basic raw material, prepared by extraction, extraction, MCI depigmentation treatment, normal phase column chromatography segmentation, chromatographic enrichment, chromatographic purification and HPLC chiral semi-preparative column resolution steps, specifically including:

[0024] A. Extraction: Maca (Latin name: Lepidium meyenii Walp.) roots are crushed and passed through a 10-100 mesh sieve to obtain material a, add an organic solvent 3-8 times the weight of material a for cold soaking and ultrasonic extraction for 2-5 times, each time for 1-3 hours, and the extract is filtered by suction Obtain filtrate b, distill and concentrate to obtain maca extract c;

[0025] B. Extraction; add water 1 to 3 times the weight of the extract c to the extract c, stir to obtain a suspension, extract 2 t...

Embodiment 1

[0056] Naturally air-dried Maca ( Lepidium meyeniiWalp.) root 50kg, coarsely crushed to 50 mesh, cold soaked with 70% acetone aqueous solution and ultrasonically extracted 3 times, each time for 60min, the extract was filtered under reduced pressure, the combined filtrate was concentrated under reduced pressure with a rotary evaporator to nothing Suspension of acetone; Leave standstill, filter out sediment, be concentrated into 10kg extract (a); Add 20kg water in extract (a), extract 5 times with the chloroform of equal volume to water, combine extraction phase, subtract Concentrate under pressure to obtain 500g medicinal extract (b); the medicinal extract (b) is packed into a column with MCI, add 1000g of 80% methanol and water mixed solvent to dissolve in the medicinal extract (b), mix the sample and put it on the column, use 90 % methanol aqueous solution 8 ~ 10L elution, collect eluent, concentrate under reduced pressure, obtain 400g extract (c); add 900g acetone to dissol...

Embodiment 2

[0058] Naturally air-dried Maca from Yuxi, Yunnan ( Lepidium meyenii Walp.) rhizome 5kg, coarsely crushed to 20 mesh, ultrasonically extracted 5 times with 80% methanol, each time for 80min, the extract was filtered under reduced pressure, the combined filtrate was concentrated under reduced pressure with a rotary evaporator to 1 / 3 of the volume of the filtrate 4; leave standstill, filter out the precipitate, concentrate to obtain 1kg extract (a); add 2kg water to the extract (a), extract 5 times with ethyl acetate equal to the volume of water, combine the extract phases, and decompress Concentrate to obtain 50g extract (b); extract extract (b) is packed with MCI, add 100g of 80% methanol and water mixed solvent to dissolve in extract (b), then put on column, use 80% methanol Elute with 3~5L of water, collect the eluent, concentrate under reduced pressure to obtain 40g of extract (c); add 100g of acetone to the extract (c), dissolve, then add 60g of 80 mesh silica gel to mix t...

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Abstract

The invention discloses sulfur-containing alkaloid as well as a preparation method and an application thereof. The sulfur-containing alkaloid is alkaloid with a 1,3-diazabicyclo[3.3.1]nonane skeletonand is prepared by taking roots of a cruciferae lepidium special resource plant maca (Latin name is Lepidium meyenii Walp.) as a basic raw material, a molecular formula of the alkaloid is C14H16N2O2S,Chinese name of the compound is (+ / -)-maca thiourea C, English name is (+ / -)-macahydantoin C, and a chemical structural formula of the compound is described in the specification. The (+ / -)-maca thiourea C shows a weak inhibiting effect on a human-derived tumor cell strain. The alkaloid disclosed by the invention is derived from a natural medical and edible plant and novel in structure and has potential antitumor activity, can be taken as a lead compound for functional food development and has a better application prospect.

Description

technical field [0001] The invention belongs to the technical field of extracting plant active chemical components, and in particular relates to a sulfur-containing alkaloid and its preparation method and application. Background technique [0002] Maca (its Latin name Lepidium meyenii Walp) (Brassicaceae), a 1-2 year-old herb belonging to the genus Brassicaceae, is native to the Andes in South America (over 3,500 meters above sea level). It is a characteristic resource plant and edible material commonly used in the local area. " and "South American ginseng", it is generally believed that it has the effect of anti-fatigue and improving the fertility of both sexes. Because Maca is rich in nutrients, rich in protein, carbohydrates, fatty acids, cellulose, vitamins and minerals, it is recommended by the United Nations World Food and Agriculture Organization as an edible safe food, and my country also listed Maca in May 2011. In the catalog of new food resources. Modern pharmac...

Claims

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Application Information

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IPC IPC(8): C07D471/08A61P35/00A23L33/105
Inventor 周敏张芮绮陈彦君韩文浩杨丽琴
Owner YUNNAN MINZU UNIV
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