Inhibiting effect of eplerenone for activation/proliferation of helper T cells of chronic heart failure patients

A technology for chronic heart failure and eplerenone, which is applied to medical preparations containing active ingredients, allergic diseases, organic active ingredients, etc., and can solve problems such as ALD escape

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A technology for chronic heart failure and eplerenone, which is applied to medical preparations containing active ingredients, allergic diseases, organic active ingredients, etc., and can solve problems such as ALD escape

CN107569495AInactive Publication Date: 2018-01-12XINJIANG MEDICAL UNIV

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[0026] 1. Materials and methods

[0027] 1.1 Materials

[0028] 1.1.1 Experimental objects and case screening conditions Experimental group: 30 cases, all inpatients in the Department of Heart Failure, The First Affiliated Hospital of Xinjiang Medical University, including 18 males and 12 females, aged 32-69 (48.34±4.86) years old . Inclusion criteria: (a) diagnosed with CHF for at least 3 months; (b) NYHA cardiac function class 2-3; exclusion criteria: (a) acute and chronic infection, inflammatory disease; (b) autoimmune disease; (c) recent unstable angina pectoris and acute myocardial infarction (within 3 months); (d) rheumatic diseases with recent (within 3 months) rheumatic activity; (e) diabetes, hyperthyroidism or other endocrine diseases; ( f) Recent use of drugs that affect the immune response (such as corticosteroids); (g) severe liver and renal insufficiency; (h) tumors; (i) pregnancy. Control group: 20 cases, all selected from outpatient health checkups, 10 males...

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Abstract

The invention discloses influences of eplerenone (EPL) for expression of mRNA and protein from the channels including Kv1.3 and the like of CD4+T lymphocytes of chronic heart failure (CHF) patients, and the result shows that eplerenone has an inhibiting effect for the activation / proliferation of the CD4+T lymphocytes of the chronic heart failure patients. The research result proves that the expression of mRNA from the channels including Kv1.3, KCa3.1 and CRAC of the CD4+T lymphocytes of the chronic heart failure patients is obviously increased compared with that of the normal group, after 30 [mu] M of eplerenone is administrated, the expression of mRNA is obviously inhibited, wherein the inhibiting for the Kv1.3 channel is the most obvious, the inhibiting rate is about 64.8% (P is smallerthan 0.01), therefore, eplerenone has good significance for detecting the protein of the Kv1.3 channel. The protein of Kv1.3 of the CHF group is increased by 120.8%, and 39.6% (P is smaller than 0.01)is inhibited after 30 [mu] M of eplerenone is added.

Description

technical field [0001] The invention relates to the inhibitory effect of eplerenone on the activation / proliferation of helper T cells in patients with chronic heart failure. Background technique [0002] Chronic heart failure (CHF) is the long-term accumulation of myocardial extracellular matrix (fibroblasts, collagen, matrix metalloproteinases, etc.), resulting in ventricular stiffness and impaired diastolic filling. The current research on the mechanism of chronic heart failure mainly involves the activation of neuroendocrine system and immune system RAAS. RAAS overactivation is the main cause of myocardial fibrosis, so ACEI and β-receptor blockers are classically used to prevent and reverse myocardial fibrosis. A large number of studies have shown that aldosterone (ALD) plays a role in coronary heart disease through its signal transduction pathway. , acute myocardial infarction, myocardial ischemia and heart failure play a key role in the occurrence and development. ACE...

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Application Information

Patent Timeline

12 Jan 2018

Publication

CN107569495A

IPC: A61K31/585; A61P9/04; A61P37/06

Inventors: 程路峰; 伊力哈木江·克尤木