Small molecule marker for predicting brain metastasis of lung cancer and application to diagnosis

A technology for brain metastases and lung cancer, applied in the field of precise diagnosis, can solve problems such as difficult acceptance by patients, detection of small lesions, difficulty in obtaining materials, etc.
CN107589196AActive Publication Date: 2018-01-16浙江高美生物科技有限公司
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
浙江高美生物科技有限公司
Publication Date
2018-01-16

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a small molecule marker for predicting brain metastasis of lung cancer and application to diagnosis, and discloses a composition for predicting the brain metastasis of the lungcancer. The small molecule marker at least comprises lysophosphatidylcholine (18:0), and preferably comprises lysophosphatidylcholine (18:0), 3-hydroxypropanoic acid and dihydrocholesterol, wherein the lysophosphatidylcholine (18:0), the 3-hydroxypropanoic acid or the dihydrocholesterol is used for singly diagnosing that the AUC (area under the curve) of the brain metastasis of the lung cancer isbetween 0.7 and 0.9, and the accuracy is medium; lysophosphatidylcholine (18:0), the 3-hydroxypropanoic acid and the dihydrocholesterol are used for jointly diagnosing that the AUC of the brain metastasis of the lung cancer and the non-brain metastasis of the lung caner is 0.928, and the accuracy is higher; the sensitivity and specificity at the optimum diagnosis critical value respectively reach0.9 or above. After centralized further verifying by independent samples, the small molecule marker has the advantages that the accuracy of the lysophosphatidylcholine (18:0), the 3-hydroxypropanoicacid or the dihydrocholesterol for jointly diganosing the brain metastasis of the lung cancer and the non-brain metastasis of the lung caner reaches 89.3%, and the clinical value is higher.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of precise diagnosis and relates to a diagnostic marker and a diagnostic kit, in particular to a small molecular marker for predicting brain metastasis of lung cancer and its application in diagnosis. Background technique

[0002] Lung cancer is a common malignant tumor. Its morbidity and mortality rank first among all kinds of malignant tumors, and it continues to rise. In the late stage of lung cancer, metastases to different organs can occur, which can cause corresponding symptoms, often bring great pain to patients, and even threaten their lives. Among them, brain metastases from lung cancer are very common. Brain metastases from lung cancer are extremely occult, without any symptoms in the early stage, and the best time window for treatment has been missed by the time of pathological diagnosis.

[0003] The gold standard for the diagnosis of brain metastases from lung cancer is pathological examination. This me...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More