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Choline eutectic solvents, preparation method and application in extraction of flavone C-glycoside of flos trollii

A low eutectic solvent and nasturtium technology, applied in the field of chemical medicine, can solve problems such as environmental damage, and achieve the effects of less impurities, fewer separation and purification steps, and lower separation and purification costs.

Inactive Publication Date: 2018-01-26
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It cannot be ignored that the consumption of large quantities of toxic solvents can cause irreversible damage to the environment

Method used

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  • Choline eutectic solvents, preparation method and application in extraction of flavone C-glycoside of flos trollii
  • Choline eutectic solvents, preparation method and application in extraction of flavone C-glycoside of flos trollii
  • Choline eutectic solvents, preparation method and application in extraction of flavone C-glycoside of flos trollii

Examples

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Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of cholines deep eutectic solvent

[0023] Different types of choline deep eutectic solvents and preparation methods are as follows:

[0024]

Embodiment 2

[0025] Example 2: Application of choline-based deep eutectic solvent in extracting flavonoid carbon glycosides from Trollica chinensis

[0026] 1. Experimental method

[0027] 1. Extraction of flavonoid glycosides from Trollica chinensis

[0028] After the nasturtium is dried, it is crushed and passed through a 50-mesh sieve. Accurately weigh 2 g of nasturtium powder, add the serial number 1-6 eutectic solution-water mixed solution (3:1, v / v) prepared in 40ml embodiment 1, ultrasonic treatment (power 250W, frequency 40kHz) 20min, under room temperature After cooling, centrifuge at 13000rpm for 10min, take the supernatant, and dilute the supernatant 10 times with water, then place it in the injection vial as the test solution, and wait for HPLC detection. The remaining supernatant was diluted with 5 times the volume of ethanol to precipitate the deep eutectic solvent, filtered through a 0.45 μm organic filter, and the filtrate was concentrated to obtain the nasturtium extract...

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Abstract

The invention discloses choline eutectic solvents, a preparation method and an application in extraction of flavone C-glycoside of flos trollii. The choline eutectic solvents have the expression: [N(CH)33CH2CH2OH]+[X.zY]- and is prepared from choline bromide or choline chloride and ZnCl2, SnCl2 or AlCl3 through mixing in a certain mole ratio, wherein when X is Br, Y is ZnCl2 or SnCl2; when X is Cl, Y is AlCl3. By means of the provided choline eutectic solvents, three important flavone C-glycosides, namely, orientin, orientin-2''-O-beta-L-galactoside and vitexin in the flos trollii can be efficiently and selectively extracted; compared with conventional extraction with methanol solvents, the extraction rate of orientin, orientin-2''-O-beta-L-galactoside and vitexin can be improved, few impurities exist in an extract, silica gel columns are not required to be repeatedly used for separation when the extract serving as the raw material is used for preparing monomers of orientin, orientin-2''-O-beta-L-galactoside and vitexin, the separation and purification steps can be greatly reduced, and the separation and purification cost can be reduced.

Description

technical field [0001] The invention belongs to the field of chemistry and medicine, and relates to the preparation and application of a deep eutectic solvent, in particular to a choline-type deep eutectic solvent, a preparation method and an application in extracting glycosides of flavonoids from nasturtium. Background technique [0002] In 2003, Abbott et al. discovered for the first time a deep eutectic solvent (Novel solvent properties of choline chloride / ureamixtures, Chem. Commun., 2003: 70-71), a solvent with excellent physical and chemical properties formed by quaternary ammonium salts and amide compounds. This solvent is non-toxic, biodegradable, and the utilization rate of atoms in the synthesis process reaches 100%, which is a new type of green solvent. A deep eutectic solvent is usually a eutectic mixture composed of a certain stoichiometric ratio of quaternary ammonium salts and hydrogen bond donors (such as compounds such as amides, carboxylic acids, and polyol...

Claims

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Application Information

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IPC IPC(8): C07C215/40C07C213/08C07D407/04C07H17/07C07H1/08
Inventor 段莉郭龙张占辉张卫红李文燕
Owner HEBEI NORMAL UNIV
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