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Single Nucleotide Polymorphism rs4377290 Detection System Related to Blood Lipid Level and Related Applications

A polymorphism, horizontal technology, applied in the determination/inspection of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problem of lack of Asian population research data and so on

Active Publication Date: 2021-10-29
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

However, almost all of these loci were originally identified in populations of European ancestry, and data from studies in Asian populations, especially Chinese populations, are lacking

Method used

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  • Single Nucleotide Polymorphism rs4377290 Detection System Related to Blood Lipid Level and Related Applications
  • Single Nucleotide Polymorphism rs4377290 Detection System Related to Blood Lipid Level and Related Applications
  • Single Nucleotide Polymorphism rs4377290 Detection System Related to Blood Lipid Level and Related Applications

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Embodiment 1

[0024] The invention is divided into two stages (preliminary screening stage and verification stage) to respectively detect and analyze the genetic variation related to the genetic variation and TC, LDL-C, HDL-C and TG.

[0025] The research population included 47,532 subjects in the first phase and 13,408 subjects in the validation phase, and the total number of East Asian populations included 61,180 in all studies. Each study was approved by the ethics committee of its research institution and the local investigating institution. All participants signed informed consent in writing.

[0026] In the first stage, a meta-analysis of the exome association study was conducted on 47,532 survey subjects in the East Asian population. 47532 subjects, from China Eye Study (CHES), China Health and Nutrition Survey (CHNS), Fangchenggang Male Health Examination Survey (FAMHES), Guizhou Bijie Type 2 Diabetes Study (GBTDS), Hong Kong University Special Research Program (HKU-TRS) ), Hubei ...

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Abstract

The present invention provides a single nucleotide polymorphism rs4377290 detection system related to blood lipid levels and its application; specifically, the present invention has determined that single nucleotide polymorphism rs4377290 is related to blood lipid levels, and provides detection from The application of reagent materials and / or instruments and equipment for detecting the polymorphism of rs4377290 site in individual samples in the preparation of a detection system for evaluating blood lipid levels and / or the risk of dyslipidemia, and also provides a method for evaluating blood lipid levels and / or a detection system for the risk of dyslipidemia, which includes: reagent materials and / or equipment for detecting the polymorphism of the rs4377290 site in the sample from the individual to be tested; wherein, rs4377290 is significantly correlated with the TC level, and the rs4377290 site T Allele carriers had higher total cholesterol levels and / or a higher risk of dyslipidemia than noncarriers.

Description

technical field [0001] The present invention relates to a single nucleotide polymorphism rs4377290 detection system related to blood lipid levels and related applications, in particular the present invention relates to reagent materials and / or instruments for detecting the polymorphism of the rs4377290 site in a sample from an individual to be tested The application of the device in preparing a detection system for assessing blood lipid levels and / or the risk of developing dyslipidemia also relates to a detection system for assessing blood lipid levels and / or the risk of developing dyslipidemia. Background technique [0002] A large number of research data show that dyslipidemia is an independent risk factor for coronary heart disease, myocardial infarction, sudden cardiac death and ischemic stroke. It causes hidden, gradual, progressive, systemic and organic damage to the body by accelerating systemic atherosclerosis. Studies have shown that for every 1% increase in the bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 顾东风黄建凤鲁向锋李宏帆杨学礼
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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