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Preparation method of film coating agent for relieving swelling and pain

A technology for reducing swelling, relieving pain, and film-coating agents. It is applied in the direction of non-central analgesics, medical preparations containing active ingredients, and anti-inflammatory agents. It can solve problems such as bacterial infections, achieve easy acceptance, delay drug release, and prepare The effect of simple process

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, symptomatic treatment is mostly used clinically, and there are bacterial infections that cannot be ignored in the treatment, especially the lesion site has affinity for Staphylococcus aureus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of a coating agent for reducing swelling and relieving pain of the present embodiment, comprising the following steps:

[0021] (1) Add 20g of flurbiprofen and 10g of budesonide into 250g of ethanol, stir to dissolve, and obtain a mixed solution for use;

[0022] (2) Sprinkle 4g ​​of cellulose evenly to let it swell naturally;

[0023] (3) Add 1.0g of laurocaprazine, stir constantly, and add ethanol to 1000mL;

[0024] (4) Adjust the pH to 6.0~7.0 and stir well to obtain a film-coating agent for reducing swelling and relieving pain.

[0025] The specific implementation process is to clean the affected area, apply the prepared coating agent for reducing swelling and relieving pain evenly on the surface of the affected area, and after it dries naturally, a gel-like film with a thickness of 1 to 3 mm will be formed. After 3 to 5 hours, the film After the drug administration is completed, tear it off from the surface of the affected area, apply new dr...

Embodiment 2

[0027] In this embodiment, on the basis of the above embodiments, the stirring process of the step (1) is further defined, which is mainly completed by a magnetic stirrer. The magnetic stirrer utilizes the characteristic of homosexual repulsion of magnetic substances to drive the magnetic stirrer to rotate by constantly changing the polarity of the two ends of the base, and the rotation of the magnetic stirrer drives the sample to rotate, so that the medicine is evenly mixed; the magnetic stirrer adopts high-quality DC The motor has low noise and stable speed regulation; the fully enclosed heating plate can be used for auxiliary heating and can be used for long-term heating; the stirring bar made of PTFE and high-quality magnetic steel is resistant to high temperature, wear and chemical Corrosion and strong magnetism; it can be mixed in a closed container, which is ideal and convenient to use; the temperature and temperature display of the agitator can be set and used for long-...

Embodiment 3

[0029] In this embodiment, on the basis of the above embodiments, the mixing container for the mixed solution in the step (3) is further defined as a 1200ml large beaker. Other steps in this embodiment are the same as those in the above embodiment, and will not be repeated here.

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PUM

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Abstract

The invention discloses a preparation method of a coating agent for reducing swelling and relieving pain, which comprises the following steps: 1) taking 20g of flurbiprofen and 10g of budesonide and adding them to 250g of ethanol, stirring and dissolving to obtain a mixed solution for use; 2) Sprinkle 4g ​​of cellulose evenly to let it swell naturally; 3) Add 1.0g of lauryl azepine, stir constantly, and add ethanol to 1000mL; 4) Adjust the pH to 6.0~7.0, stir well, and it is ready to use A film agent for reducing swelling and relieving pain. In the present invention, flurbiprofen and budesonide have obvious effects on inhibiting bacteria, and flurbiprofen and budesonide are prepared into medicines. Due to the laurocapram transdermal technology, the skin and limb penetration of medicines has been increased, showing The superior curative effect of the coating agent on chronic eczema; the swelling and pain-relieving coating agent made of cellulose has no greasy feeling, is easy to spread, has strong adhesion, has a certain tear resistance strength, is easy to use, and is good for the skin. Non-irritating.

Description

technical field [0001] The invention relates to the field of film-coating agent preparation, in particular to a method for preparing a film-coating agent for reducing swelling and alleviating pain. Background technique [0002] In life, there are often redness, swelling and pain in the body parts due to various reasons. At this time, it is very important to reduce swelling and relieve pain in time, because only in this way can the damaged parts recover as soon as possible. In fact, there are many ways to reduce swelling and relieve pain. The common ones are massage, cold compress, etc. Of course, the methods used are different according to different injured parts. [0003] Flurbiprofen is a propionic acid non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects, and is clinically used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and other diseases. Oral administration of ordinary tablets can cause side eff...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K9/70A61K47/38A61K47/22A61P29/00A61P19/02A61P19/08A61P31/04A61K31/192
CPCA61K31/192A61K9/7015A61K31/58A61K47/22A61K47/38A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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