Batch manufacturing method of cuspate three-layer biofilm

Abstract

The present invention provides a batch production method for a pointed three-layer biofilm, comprising the following steps: 1) pre-making a long strip model with a star-shaped cross-section, four "V"-shaped apexes, and the apex angle and the fracture line cross-section matching; 2) Dip the strip model into the first solution layer, the second solution layer, and the third solution layer in turn. The first solution forms an elastic layer, which is a dense degradable or non-degradable biofilm, and the second solution layer forms a drug layer. It is encapsulated with a drug sustained-release system that promotes bone healing. The material is a degradable or absorbable substance that is biocompatible with human bone. The third solution layer forms a guide layer, and the material is biocompatible with human bone. Good compatibility with degradable or non-degradable, absorbent or non-absorbable porous loose substances; 3) After the air-drying shape of the biological microstructure membrane is fixed, according to the required size, the prepared biological microstructure membrane is elliptical along the cross-section of the elongated model. The circular biofilm after cutting was cut off from the top corner of the elongated model.

Description

technical field [0001] The invention relates to a batch production method of a pointed three-layer biofilm. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reaction ...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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