Method For Diagnosis And Prognosis Of Chronic Heart Failure

A technology of heart failure and algorithms, applied in the field of molecular biology, can solve the problems of high morbidity and mortality of heart failure

Inactive Publication Date: 2018-02-09
AGENCY FOR SCI TECH & RES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite advances in treatment, morbidity and mortality from heart failure remains high (approximately 50% at 5 years) and consumes approximately 2% of health care budgets in many economies [3-6]

Method used

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  • Method For Diagnosis And Prognosis Of Chronic Heart Failure
  • Method For Diagnosis And Prognosis Of Chronic Heart Failure
  • Method For Diagnosis And Prognosis Of Chronic Heart Failure

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Embodiment Construction

[0069] Timely diagnosis, accurate classification of heart failure subtypes (including but not limited to heart failure with reduced left ventricular ejection fraction (HFREF), heart failure with preserved left ventricular ejection fraction (HFPEF), etc.) The management and treatment of heart failure are of great importance. An attractive approach is to use circulating biomarkers [14]. An established circulating biomarker in heart failure is cardiac natriuretic peptide, B-type natriuretic peptide (BNP) and its co-secreted congener, the N-terminal hormone probrain natriuretic peptide (NT-proBNP). Both have demonstrated diagnostic utility in acute heart failure and are independently associated with prognosis in all stages of heart failure, making them included in all major international guidelines for the diagnosis and management of heart failure [14,15]. However, confounding factors including age, renal function, obesity, and atrial fibrillation do affect its diagnostic perform...

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Abstract

Present application relates to methods for determining whether a subject has heart failure or is at risk of having heart failure, specifically that of heart failure with reduced left ventricular ejection fraction (HFREF) and a heart failure with preserved left ventricular ejection fraction (HFPEF), comprising determining the level of selected miRNA(s) observed in a sample obtained from the subjectand wherein an altered level of the miRNA(s) compared to control indicates that the subject has heart failure or is at risk of developing heart failure. Also encompassed are methods of determining analtered risk of death or disease progression to hospitalization and death based on alteration of selected miRNAs in a sample from the subject and kits thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority from Singapore Patent Application No. 10201503644Q filed on May 8, 2015, the contents of which are hereby incorporated by reference in their entirety for all purposes. technical field [0003] The present invention relates generally to the field of molecular biology. In particular, the invention relates to the detection and diagnosis of heart failure using biomarkers. Background technique [0004] Cardiovascular disease, including heart failure, is a major health problem, accounting for approximately 30% of human deaths worldwide [1]. Heart failure is also the leading cause of hospitalization in adults over the age of 65 worldwide [2]. Adults in middle age have a 20% lifetime risk of developing heart failure. Despite advances in treatment, morbidity and mortality from heart failure remains high (approximately 50% at 5 years) and consumes approximately 2% of health care...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 邹瑞阳周砺寒朱兴奋A·M·理查兹黄莉莉蓝淑彬
Owner AGENCY FOR SCI TECH & RES
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