Medicine for treating heart qi deficiency, blood stasis and edema syndromes of chronic cardiac failure and preparation method of medicine

Abstract

The invention discloses a medicine for treating heart qi deficiency, blood stasis and edema syndromes of chronic cardiac failure and a preparation method of the medicine. The medicine is prepared such medicinal raw materials as astragali radix, roasted rhizoma atractylodis macrocephalae, dried ginger, prepared leech, roasted semen plantaginis, poria cocos, roasted fructus aurantii immaturus, roasted semen lepidii and raw liquorice. The medicine has the beneficial effects that compared with internationally recognized treatment by use of Western medicines hydrochlorothiazide and acertil, sugar-free granules, which are developed based on the traditional Chinese medicine theory of correlation between heart and spleen, according to the treatment rules of warning heart and spleen, promoting circulation of fluid and expelling stasis and by use of a class 6 new traditional Chinese medicine preparation process, are capable of obviously improving the LVEF (Left Ventricular Ejection Fraction) and the LVFS (Left Ventricular Fractional Shortening) of chronic cardiac failure suffering rats, and therefore, the whole and radius contraction functions of the left ventricles of the rats having the heart qi deficiency, blood stasis and edema syndromes can be obviously improved; the medicine has the trend of improving the load of the left ventricles of the rats having the heart qi deficiency, blood stasis and edema syndromes by reducing the BNP (Brain Natriuretic Peptide) blood concentration, and therefore, the diastolic function of the left ventricles of the rats having the heart qi deficiency, blood stasis and edema syndromes can be improved. The medicine has the advantages of remarkable curative effect, no toxic and side effects and the like.

Description

technical field The invention relates to the technical field of pharmacy, in particular to a medicine for treating chronic heart failure with syndrome of heart-qi deficiency combined with blood stasis and edema and a preparation method thereof. Background technique Chronic heart failure (CHF), also known as congestive heart failure, refers to a clinical syndrome in which chronic cardiomyopathy and ventricular contractility are weakened due to long-term pressure or volume overload, and cardiac output cannot be maintained. The goal of treating heart failure is not only to improve symptoms and improve the quality of life, but also to target the mechanism of myocardial remodeling, delay and prevent the development of myocardial remodeling, and reduce the hospitalization rate and mortality of heart failure. Most patients have a history of heart disease, and treatment of the cause will significantly improve the prognosis of heart failure. Coronary heart disease, hypertension, an...

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Problems solved by technology

To date, the mechanism of heart failure with preserved LV ejection fraction (or LV diastolic dysfunction) is unknown and there is no drug available for the treatment of LV diastolic dysfunction

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