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Traditional Chinese medicine composition, preparation and preparation method for preventing or treating liver fibrosis and cirrhosis

A composition and technology of traditional Chinese medicine, applied in the field of preparation of traditional Chinese medicine compound products and preparations thereof, can solve the problems of unsuitability for combined use, reduced liver metabolism in patients with liver disease, etc., achieve no toxic side effects, improve drug quality stability, The effect of improving liver cirrhosis symptoms

Active Publication Date: 2021-04-30
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, because not only western medicines are metabolized by the liver, but also traditional Chinese medicines are also metabolized by the liver, and the metabolic capacity of the liver is reduced in patients with liver disease. Therefore, it is not suitable for the combination of many kinds of traditional Chinese medicines and the use of large doses of traditional Chinese medicine compositions or preparations.

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  • Traditional Chinese medicine composition, preparation and preparation method for preventing or treating liver fibrosis and cirrhosis
  • Traditional Chinese medicine composition, preparation and preparation method for preventing or treating liver fibrosis and cirrhosis
  • Traditional Chinese medicine composition, preparation and preparation method for preventing or treating liver fibrosis and cirrhosis

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preparation example Construction

[0056] Another object of the present invention is to provide a Chinese medicine composition preparation for preventing or treating liver fibrosis and cirrhosis and a preparation method thereof, the preparation is a liquid preparation, and the preparation method comprises the following steps:

[0057] In step (1), the crude drug weighed according to the components of the traditional Chinese medicine is decocted with water or extracted three times under reflux;

[0058] In step (2), the decocted or refluxed extracted liquids are combined and filtered to obtain the liquid preparation of the traditional Chinese medicine composition.

[0059] In the present invention, the preparation method of the liquid preparation of the traditional Chinese medicine composition is simple, and the patient can decoct and take it at home; or it can be decocted or refluxed and extracted in a medical institution, sealed and packaged, and the patient can take it after taking it.

[0060] In step 1, 10-...

Embodiment 1

[0092] Embodiment 1 liquid preparation

[0093] The composition of the prescription is as follows: 30g of curcumin, 25g of silymarin and 70g of astragalus.

[0094] Adopt following preparation method to obtain liquid preparation:

[0095] Take three raw materials, curcumin 30g, silymarin 25g and astragalus 70g, add water and decoct three times, add water to 10 times the weight of the medicine for the first time, decoct for 1 hour, add water for the second time 5 times, decoct for 0.5h, and decoct for the third time Add water 5 times, decoct for 0.5h, combine the liquid after decoction, filter, and divide the filtrate into three equal parts.

Embodiment 2

[0096] Embodiment 2 liquid preparation

[0097] The composition of the prescription is as follows: curcumin 30g, silymarin 25g, astragalus 70g, salvia miltiorrhiza 50g, poria cocos 30g and bupleurum 30g.

[0098] Adopt following preparation method to obtain liquid preparation:

[0099] Take six kinds of raw materials, curcumin 30g, silymarin 25g, astragalus 70g, salvia miltiorrhiza 50g, poria cocos 30g and Bupleurum bupleuri 30g, add water and reflux for extraction three times, add water for the first time to 10 times the weight of the drug, reflux for 1h, add water for the second time 5 times, reflux extraction for 0.5h, add water 5 times for the third time, reflux extraction for 0.5h, after the reflux is completed, combine the liquid, filter, and divide the filtrate into three equal parts.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition, preparation and preparation method for preventing or treating liver fibrosis and liver cirrhosis. The active ingredients of the traditional Chinese medicine composition / preparation mainly include curcumin, silymarin and astragalus, and salvia miltiorrhiza, poria cocos and chai chai are also added. Hu, processed into liquid or solid preparations. The present invention is based on the theory of traditional Chinese medicine and modern pathological research, and verified by clinical efficacy, the Chinese medicine composition / preparation has preventive and therapeutic effects on liver fibrosis and liver cirrhosis caused by viral hepatitis, alcoholic fatty liver and non-alcoholic fatty liver, etc. , has strong anti-inflammatory, anti-fibrosis, anti-oxidation, immune regulation and other effects, and can comprehensively protect the liver.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound product and a preparation method thereof, in particular to a traditional Chinese medicine composition, a preparation and a preparation method for preventing or treating liver fibrosis and cirrhosis. Background technique [0002] my country is a country with a large number of liver diseases. Various etiologies (such as viruses, alcohol, immunity, drug poisons, etc.) cause continuous inflammatory damage to the liver, and the repair of damage is accompanied by changes in the immune system and activation of hepatic stellate cells. The diffuse excess cells in the liver The deposition of extracellular matrix (mainly collagen) eventually leads to liver fibrosis and cirrhosis. Liver fibrosis is the pre-pathological change of liver cirrhosis, which is reversible. Liver cirrhosis is the result of further development of liver fibrosis. If it is not intervened or treated in time, it may progress to de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K31/357A61K36/481A61K36/537A61P1/16A61P31/14A61P31/20A61P43/00
CPCA61K31/12A61K31/357A61K36/076A61K36/233A61K36/481A61K36/537A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 陈永平陈达之肖茜茜许烂漫李骥卢明芹金晓芝
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV