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Carbocisteine oral solution and preparation method thereof

A technology of carbocisteine ​​and an oral solution, which is applied in the field of medicine, can solve the problems of troublesome taking, cumbersome process, difficult to conceal the bad taste of medicine, etc., and achieves the effects of low cost, simple process and easy industrial production.

Inactive Publication Date: 2018-02-23
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cough and phlegm drugs currently on the market are mainly ordinary solid preparations, which are cumbersome to process and troublesome to take, and it is difficult to cover up the bad taste of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A carbocisteine ​​oral solution is made of the following raw materials in weight ratio: 50 parts of carbocisteine, 10 parts of glycerin, 10 parts of lemon juice, 5 parts of loquat, 1 part of tert-butylhydroxyanisole, 1 part of hydroxypropyl-β-cyclodextrin, 0.1 part of lactose, appropriate amount of pH regulator.

[0023] A preparation method for carbocisteine ​​oral solution, comprising the steps of:

[0024] (1) Take glycerin, lemon juice, and loquat dew in the formula amount, add ultrapure water, and ultrasonically treat for 10 minutes;

[0025] (2) Add carbocisteine ​​in the formula amount to the solution in step (1), heat to boiling, then stir and mix uniformly;

[0026] (3) Add tert-butylhydroxyanisole, hydroxypropyl-β-cyclodextrin, and lactose in a boiling state, keep boiling for 5 minutes, let stand, and cool to room temperature;

[0027] (4) add pH adjuster, stir well, make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral solution;

[0028] (5) ...

Embodiment 2

[0030] A carbocisteine ​​oral solution is made from raw materials in the following weight ratio: 60 parts of carbocisteine, 15 parts of glycerin, 13 parts of lemon juice, 8 parts of loquat dew, 5 parts of tert-butyl hydroxyanisole, 5 parts of hydroxypropyl-β-cyclodextrin, 0.5 part of lactose, appropriate amount of pH regulator.

[0031] A preparation method for carbocisteine ​​oral solution, comprising the steps of:

[0032] (1) Take glycerin, lemon juice, and loquat dew in the formula amount, add ultrapure water, and ultrasonically treat for 12 minutes;

[0033] (2) Add carbocisteine ​​in the formula amount to the solution in step (1), heat to boiling, then stir and mix uniformly;

[0034] (3) Add tert-butylhydroxyanisole, hydroxypropyl-β-cyclodextrin, and lactose in a boiling state, keep boiling for 8 minutes, let stand, and cool to room temperature;

[0035] (4) add pH regulator, stir evenly,

[0036] Make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral so...

Embodiment 3

[0039] A carbocisteine ​​oral solution is made from the raw materials in the following weight ratio: 60 parts of carbocisteine, 15 parts of glycerin, 13 parts of lemon juice, 8 parts of loquat dew, 5 parts of D-ascorbic acid, polyethylene glycol 5 parts of alcohol, 0.5 part of lactose, and an appropriate amount of pH regulator.

[0040] A preparation method for carbocisteine ​​oral solution, comprising the steps of:

[0041] (1) Take glycerin, lemon juice, and loquat dew in the formula amount, add ultrapure water, and ultrasonically treat for 10 minutes;

[0042] (2) Add carbocisteine ​​in the formula amount to the solution in step (1), heat to boiling, then stir and mix uniformly;

[0043] (3) Add D-ascorbic acid, polyethylene glycol, and lactose in a boiling state, keep boiling for 5 minutes, let stand, and cool to room temperature;

[0044] (4) add pH adjuster, stir well, make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral solution;

[0045] (5) the carbo...

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Abstract

The invention provides a carbocisteine ​​oral solution and a preparation method thereof, relating to the technical field of medicine, comprising carbocisteine, glycerin, lemon juice, loquat, antioxidant, solution stabilizer, flavoring agent, and pH regulator; The method comprises the following steps: (1) taking the glycerin, lemon juice and loquat dew of the formula quantity, adding ultrapure water, and ultrasonic treatment for 10-12min; (2) adding the carbocisteine ​​of the formula quantity into the solution in step (1) , heated to boiling, then stirred, and mixed evenly; (3) adding antioxidant, solution stabilizer, flavoring agent in boiling state, keeping boiling for 5‑8min, standing, and cooling to room temperature; (4) adding pH adjustment medicament, stir evenly, make the pH value of solution be 6.5-7.0, make carbocisteine ​​oral solution. The method of the invention has simple process and low cost, and the obtained carbocisteine ​​oral solution has good water solubility and is easy to industrialized production, and solves the problems of carbocisteine ​​taste discomfort and low bioavailability.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a carbocisteine ​​oral solution and a preparation method thereof. Background technique [0002] Among the deaths caused by various diseases in my country, the deaths caused by respiratory diseases occupy the first place, and the number is still increasing year by year. In the process of urbanization, the environment is deteriorating day by day. In addition to industrial pollution, harmful gases emitted by motor vehicles seriously threaten our respiratory health, and may even induce the onset and development of other latent diseases, such as pneumonia and chronic pharyngitis. , chronic bronchitis, bronchiectasis, lung abscess and cavitary tuberculosis. At this time, in addition to prescribing the right medicine for respiratory diseases, it is also necessary to apply antitussive and expectorant drugs appropriately to relieve cough. [0003] The current application of antitussive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/198A61K47/46A61K47/22A61K47/40A61K47/10A61P11/12
CPCA61K9/08A61K9/0053A61K31/198A61K47/10A61K47/22A61K47/40A61K47/46
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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