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Artificial lens with hydrophilic-medicine sustained release synergistic function, and preparation method thereof

An intraocular lens and drug technology, applied in intraocular lens, prosthesis, medical science and other directions, can solve the problems of ineffective resistance to cell adhesion, complex surface modification process, etc., and achieve a simple manufacturing process, low cost, and easy disinfection. Effect

Active Publication Date: 2018-03-06
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drug-loaded intraocular lens can inhibit the proliferation of lens epithelial cells relatively well, there are also some problems: the surface modification process is complicated, and the intraocular lens cannot effectively resist cell adhesion in the early stage of implantation

Method used

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  • Artificial lens with hydrophilic-medicine sustained release synergistic function, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 5 mg / mL polyethylene glycol methacrylate, 5 mg / mL doxorubicin, 5 mg / mL dopamine and 5 mg / mL polyethyleneimine and mix them uniformly in the aqueous solution system, put them into the intraocular lens, adjust pH to 10, light-blocked magnetic stirring for 0.5 hours, and ultrapure water washing to obtain a hydrophilic-drug-loaded synergistic functional coating modified intraocular lens.

Embodiment 2

[0022] Take 0.2 mg / mL sulfobetaine methacrylate, 0.1 mg / mL paclitaxel, 0.5 mg / mL dopamine and 0.2 mg / mL polyamidoamine-type dendrimers in the aqueous system, mix them uniformly, put them into artificial The lens was adjusted to a pH of 8.5, light-blocked and magnetically stirred for 12 hours, and washed with ultrapure water to obtain an intraocular lens modified with a hydrophilic-drug-loading synergistic functional coating.

Embodiment 3

[0024] Take 2 mg / mL phosphatidylcholine sterol methacrylate, 2 mg / mL rapamycin, and 2 mg / mL dopamine and mix them uniformly in the aqueous solution system, put them into the intraocular lens, adjust the pH to 9, and close the light Magnetically stirred for 6 hours, washed with ultrapure water, and a hydrophilic-drug-loaded synergistic functional coating-modified intraocular lens was obtained.

[0025] The principle of the present invention is: dopamine is a neurotransmitter existing in a living body. Studies have found that dopamine can undergo self-polymerization under certain conditions to form polydopamine, which is very similar to the naturally occurring mussel adhesive protein. Polydopamine can adhere to almost all material surfaces to form a bonding interface. The activation of hydrogen makes it easy to chemically bond compounds with active groups such as amino groups, mercapto groups, and carbon-carbon double bonds to the surface of polydopamine. In the present inventi...

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Abstract

The invention relates to an artificial lens with a hydrophilic-medicine sustained release synergistic function, and a preparation method thereof. A medicine-loading-hydrophilic multifunctional coatingis modified on the surface of the artificial lens, and the synergistic effect of resisting cell adhesion at an early stage after implantation and resisting lens epithelia cell proliferation at middleand late stage is achieved, so that the occurrence rate of posterior capsule opacification can be reduced and a high-biocompatibility artificial lens is obtained; a hydrophilic-medicine-loading multifunctional modification layer is constructed on the surface of the artificial lens by a one-pot method, the manufacturing process is simple and low in cost, the tedious steps required by surface modification in the past are avoided, and the artificial lens can be applied to the surface of a three-dimensional implantable device with various complex shape structures. The manufactured zwitterionic modified artificial lens is convenient to disinfect, packaging and transport, and is an artificial lens industrialized product which is low in cost, convenient and practical.

Description

technical field [0001] The invention specifically relates to the technical field of ophthalmic medical implant materials and device surface modification, in particular to an intraocular lens with synergistic functions of hydrophilic and drug sustained release and a preparation method thereof. Background technique [0002] Cataract is the most common blinding eye disease. Phacoemulsification combined with intraocular lens implantation is an effective method for clinical treatment of cataract. Various intraocular lenses, including hydrophilic and hydrophobic intraocular lenses, generally have foreign body reactions after being implanted in the human eye for a long time, thereby greatly reducing the visual quality. Post-cataract, that is, the opacity of the lens capsule after intraocular lens implantation, is the main complication that seriously affects the vision recovery of patients after intraocular lens implantation. In general, the incidence of post-cataract in adults wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61F2/16
CPCA61F2/0077A61F2/1602A61F2210/00A61L27/34A61L27/54A61L2300/216A61L2300/232A61L2300/416A61L2300/602A61L2300/606C08L33/02
Inventor 林全愧韩月梅刘思豪陈浩
Owner WENZHOU MEDICAL UNIV
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